NOC-12

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Nitric oxide donor

Nitric oxide (NO) donor. The half-life time of 0.1mM NOC-12 is 100 min. at 37°C in 0.1M PBS, pH 7.4.

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Alternative Name	1-Hydroxy-2-oxo-3-(N-ethyl-2-aminoethyl)-3-ethyl-1-triazene
Appearance	White powder.
CAS	146724-89-2
Formula	C₆H₁₆N₄O₂
MW	176.2
Purity	≥97% (HPLC)
Solubility	Soluble in 0.1M NaOH (10mg/ml)

Use/Stability	As indicated on product label or CoA when stored as recommended. Prepare fresh stock solution prior to use. Store in ice bath during the experiment. Stock solution will lose 5% of activity per day when stored at -20°C.
Handling	Protect from light and moisture. Packaged under inert gas.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Excellent absorption enhancing characteristics of NO donors for improving the intestinal absorption of poorly absorbable compound compared with conventional absorption enhancers: G. Fetih, et al.; Drug Metab. Pharmacokinet. 21, 222 (2006), Abstract — Full Text
Characterization of the influence of nitric oxide donors on intestinal absorption of macromolecules: K. Takahashi, et al.; Int. J. Pharm. 286, 89 (2004), Abstract
New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)

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