NNGH

BML-PI115

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MMP inhibitor

Potent inhibitor of human stromelysin-1 (MMP-3), K_i=0.13 µM. Also inhibits MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 (metalloelastase), MMP-13, MMP-14, and MMP-20.

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Product Details

Alternative Name	N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
Appearance	White solid.
CAS	161314-17-6
Couple Target	MMP
Couple Type	Inhibitor
Formula	C₁₃H₂₀N₂O₅S
MW	316.4
Purity	≥99% (TLC)
Solubility	Soluble in DMSO (30mg/ml) or 100% ethanol (8mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells: Solga, R., Behrens, J., et al.; Eur. J. Cell Biol. 98, 151046 (2019), Abstract
MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology: Ijichi, K., Brown, G. D., et al.; Glia 61, 765 (2013), Abstract
Catalytic domain of MMP20 (Enamelysin) – the NMR structure of a new matrix metalloproteinase: Y. Arendt et al.; FEBS Lett. 581, 4723 (2007), Abstract
A high-affinity carbohydrate-containing inhibitor of matrix metalloproteinases: V. Calderone; Chem. Med. Chem 1, 598 (2006), Abstract
Crystal structure of the catalytic domain of human matrix metalloproteinase 10: I. Bertini et al.; J. Mol. Biol. 336, 707 (2004), Abstract
Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase: A. Y. Jeng et al.; Bioorg. Med. Chem. Lett. 8, 897 (1998), Abstract
Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits: L. J. MacPherson et al.; J. Med. Chem. 40, 2525 (1997), Abstract

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NNGH

BML-PI115

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