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Niltubacin

BML-GR363

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HDAC inhibitor

Negative control for Tubacin (tubulin acetylation inducer), a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6. Concentration of niltubacin in cell culture experiments typically ranges from 2-20µM.

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Product Details

Alternative Name	7-(4-((2R,4R,6S)-4-((4,5-dipenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenylcarbamoyl)heptanoic acid
Appearance	White solid.
Couple Target	HDAC, HDAC6
Couple Type	Inhibitor
Formula	C₄₁H₄₂N₂O₇S
MW	706.9
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (6 mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least one year after receipt when stored at -80°C.
Short Term Storage	-20°C
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma: M. Nassar, et al.; Sci. Rep. 7, 8022 (2017), Application(s): Measurement of cell index against different concentration, Abstract — Full Text
Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero: Salmi, M., Bruneau, N., et al.; Brain 136, 2457 (2013), Abstract
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents: M. Namdar, et al.; Proc. Natl. Acad. Sci. USA 107, 20003 (2010), Abstract — Full Text
Histone deacetylase 6 interacts with the microtubule-associated protein tau: H. Ding, et al.; J. Neurochem. 106, 2119 (2008), Abstract — Full Text
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation: S.J. Haggarty, et al.; Proc. Natl. Acad. Sci. USA 100, 4389 (2003), Abstract — Full Text

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Alternative Name	N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanyl]methyl}-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl}phenyl)-N’-hydroxyoctanediamide
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Niltubacin

BML-GR363

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Niltubacin

BML-GR363

Product Details

Handling & Storage

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FLUOR DE LYS® HDAC6 fluorometric drug discovery kit

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Manuals And Inserts

Certificate of Analysis

SDS

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