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Niguldipine . HCl

BML-CA216

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Ca²⁺ channel blocker

A classic L-type Ca²⁺ channel blocker (IC₅₀=75nM) which can also inhibit T-type Ca²⁺ channels (IC₅₀=244nM). It is a novel inhibitor of drug transport by p-glycoprotein (both stereoisomers are equipotent at inhibition of p-glycoprotein).

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Product Details

Alternative Name	(±)-Niguldipine . hydrochloride, (±)-1,4-Dihydro-2,6-dimethyl-4-(3’-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4’,4’-diphenyl-1’-piperidinyl)propylmethyl ester . HCl
Appearance	Yellow crystalline solid.
CAS	119934-51-9
Couple Target	Calcium channel
Couple Type	Blocker
Formula	C₃₆H₃₉N₃O₆ . HCl
MW	646.2
Purity	≥95% (TLC)
Solubility	Soluble in DMSO or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells: W. Stengel, et al.; Eur. J. Pharmacol. 342, 339 (1998), Abstract
Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein: V. Hollt, et al.; Biochem. Pharmacol. 43, 2601 (1992), Abstract
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices: J.P. Robinson & D.A. Kendall; Br. J. Pharmacol. 100, 3 (1990), Abstract
Stereoselective binding of niguldipine enantiomers to alpha 1A-adrenoceptors labeled with [3H]5-methyl-urapidil: I. Graziadei, et al.; Eur. J. Pharmacol. 172, 329 (1989), Abstract

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