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- Potassium ionophore used to disrupt intracellular H+and K+levels
- Compound used to alter cell volume, membrane potential, and pH
- NALP3 inflammasome activator
Nigericin is an antibiotic isolated Streptomyces hygroscopicus that acts as an H+, K+, Na+, Pb2+ ionophore. Similarly to Valinomycin (Prod. No. BML-KC140), Nigericin is most commonly an antiporter of H+ and K+ across biological membranes. Nigericin stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential. Nigericin also activates NALP3 inflammasome and induces the release of IL-1β.
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| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | MSU (crystals), Uric Acid (crystals) |
|---|---|
| CAS | 1198-77-2 |
| Couple Type | Activator |
| Alternative Name | NACHT-, LRR- and PYD-containing protein 3, CIAS1, Cryopyrin, Cold autoinflammatory syndrome 1 protein, PYPAF1, PYRIN-containing APAF1-like protein 1 |
|---|---|
| Application | IHC (FS), IP, WB |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
MITO-ID® Membrane potential detection kit
ENZ-51018
The only mitochondria membrane potential assay that monitors energetic status using a simple mix-and-read, no-wash protocol
| Application | Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS |
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