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Nicardipine . hydrochloride

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Ca²⁺ channel inhibitor

Ca²⁺ channel antagonist. Antihypertensive.

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Alternative Name	YC-93 . HCl, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[methyl(phenylmethyl)amino]ethyl ester . HCl
Appearance	Light yellow solid.
CAS	54527-84-3
Couple Target	Calcium channel
Couple Type	Inhibitor
Formula	C₂₆H₂₉N₃O₆ . HCl
Identity	Determined by IR.
MI	14: 6495
MW	479.5 . 36.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (1mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water; insoluble in 0.1M NaOH.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

1,4-Dihydropyridine activators and antagonists: structural and functional distinctions: D.J. Triggle & D. Rampe; TIPS 10, 507 (1989), Abstract
Mechanisms underlying the cardiovascular action of a new dihydropyridine vasodilator YC-93: K. Satoh, et al.; Clin. Exp. Pharmacol. Physiol. 7, 249 (1980), Abstract

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