Nerve growth factor receptor (human):Fc (human), (recombinant)

NGFR, TNFRSF 16, Low-affinity nerve growth factor receptor, p75NTR, p75 neurotrophin receptor, CD271

1mg/ml after reconstitution.

<0.1EU/µg purified protein (LAL test; Bio Whittaker).

Lyophilized. Contains PBS.

~80kDa (under reducing conditions).

≥90% (SDS-PAGE)

Reconstitute in 50µl sterile water. Further dilutions can be made with medium containing 5% fetal calf serum.

Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75^NTR) (aa 1-250) is fused to the Fc portion of human IgG1.

Binds human, mouse and rat NGF (nerve growth factor).

Historical data has shown that NGFR inhibits rat NGF-mediated activation of rat PC12 cells.

P08138