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Necrox-2™

ALX-430-166

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Necrosis inhibitor

Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1µM NecroX™-2 prevented ~50% cell death in H9C2 cells exposed to 400µM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro.

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Product Details

Alternative Name	[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
Appearance	Gray powder.
Application Notes	For in vitro applications, dissolve in DMSO to 20-50mM stock solution and dilute further in cell culture media. Treat cells with 30µM to 0.1µM final concentration. Optimal conditions must be determined individually for each application.
Formula	C₂₅H₃₂N₄O₄S₂
MW	516.7
Purity	≥95% (NMR, LCMS)
Solubility	Soluble in DMSO (>10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Necrocide 1 Mediates a Non-Apoptotic Necrotic Cell Death and Immunogenic Response in Human Cancer Cells: J. Zhang, et al.; Cell Death Dis. 14, 238 (2023), Abstract
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis: Liu, X., Nie, L., et al.; Nat. Cell Biol. 25, 404 (2023), Abstract
Necrosis triggered byi>Mycobacterium tuberculosis/i>alters macrophage triglyceride metabolism and inflammatory response in a DGAT1 – dependent manner: Jaisinghani, N., Dawa, S., et al.; bioRxiv , (2017)
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells: You, B. R., Han, B. R., et al.; Oncotarget 8, 17726 (2017), Abstract
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity: Q. Li, et al.; Nat. Commun. 6, 6183 (2015), Application(s): Cell Culture, Abstract
Necrotic cell death in atherosclerosis: W. Martinet, et al.; Basic Res. Cardiol. 106, 749 (2011), Abstract
NecroX as a novel class of mitochondrial reactive oxygen species and ONOO(-) scavenger: H.J. Kim, et al.; Arch. Pharm. Res. 33, 1813 (2010), Abstract

Related Products

Necrox-5™ . methanesulfonate

ALX-430-167

Necrosis inhibitor

5 citations

Alternative Name	[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine
Purity	≥95% (HPLC)

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Necrox-2™

ALX-430-166

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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