NBQX

ALX-550-044

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AMPA/kainate receptor antagonist

Most potent and selective AMPA/kainate receptor antagonist. For the more soluble form see NBQX . disodium salt (Prod. No. ALX-550-272).

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Product Details

Alternative Name	2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo(f)-quinoxaline, 6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2,3-dione
Appearance	Yellow crystalline powder.
CAS	118876-58-7
Couple Target	AMPA receptor, Kainate receptor
Couple Type	Inhibitor, Ligand
Formula	C₁₂H₈N₄O₆S
MW	336.3
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO. A 1mM aqueous solution may be prepared by taking up in >2.5 eq. of NaOH and backtitrating to pH 8.0-8.5 with conc. HCl.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline: H. Bernert & L. Turski; PNAS 93, 5235 (1996), Abstract
Emerging treatments for stroke in humans: W.J. Koroshetz & M.A. Moskowitz; TIPS 17, 227 (1996), (Review), Abstract
Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy: T. Namba, et al.; Brain Res. 638, 36 (1994), Abstract
The pharmacology of AMPA receptors and their antagonists: M.J. Sheardown; Stroke 24, I146 (1993), Abstract
A comparison of the actions of agonists and antagonists at non-NMDA receptors of C fibres and motoneurones of the immature rat spinal cord in vitro: P. Pook, et al.; Br. J. Pharmacol. 108, 179 (1993), Abstract
AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?: A.M. Buchan, et al.; Stroke 24, I148 (1993), Abstract
The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl- benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model: R. Gill, et al.; Brain Res. 580, 35 (1992), Abstract
Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution: J.C. Randle, et al.; Eur. J. Pharmacol. 215, 237 (1992), Abstract
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia: M.J. Sheardown, et al.; Science 247, 571 (1990), Abstract
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP: D. Muller, et al.; Science 242, 1694 (1988), Abstract

Related Products

NBQX . disodium salt

ALX-550-272

AMPA/kainate receptor antagonist

Alternative Name	2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo(f)-quinoxaline . 2Na, 6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2,3-dione . 2Na
CAS	118876-58-7 (non-salt)
Couple Type	Inhibitor, Ligand
Purity	≥98% (HPLC)

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NBQX

ALX-550-044

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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