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NBD peptide / NF-κB blocker (cell permeable)

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For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.

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Alternative Name	NEMO-binding domain peptide
Concentration	10mM
Formula	C₁₂₁H₂₀₂N₄₈O₃₂
Formulation	Liquid. In sterile PBS.
MW	2841.2
Purity	≥95% (HPLC)
Quantity	50µl
Sequence	GRKKRRQRRR-GG-TALDWSWLQTE-amide

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Keep on ice at all times. Protect from moisture. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Short Term Storage	-20°C
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque: A. Sakamoto, et al.; JCI Insight 8, e154922 (2023), Abstract
Targeting of NF-κB to Dendritic Spines Is Required for Synaptic Signaling and Spine Development: E.C. Dresselhaus, et al.; J. Neurosci. 38, 4093 (2018), Abstract — Full Text
CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury: H. Akahori, et al.; Nat. Commun. 6, 7792 (2015), Application(s): Intraperitoneal administration in mice, Abstract
Improvement of cardiac contractile function by peptide-based inhibition of NF-kappaB in the utrophin/dystrophin-deficient murine model of muscular dystrophy: D.A. Delfin, et al.; J. Transl. Med. 9, 68 (2011), Abstract — Full Text
Disruption of IKK-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to HDAC inhibitors: Y. Dai, et al.; J. Biol. Chem. 286, 34036 (2011), Abstract
Selective inhibition of NF-kappaB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo: E. Jimi, et al.; Nature Med. 10, 617 (2004), Abstract
Characterization of the Ikappa B-kinase NEMO binding domain: M.J. May, et al.; J. Biol. Chem. 277, 45992 (2002), Abstract
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex: M.J. May, et al.; Science 289, 1550 (2000), Abstract

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