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N-(p-Amylcinnamoyl)anthranilic acid

BML-EI178

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Inhibitor of PLA₂ and TRP channels

ACA is a close structural analog of the PLA₂ inhibitor, ONO-RS-082 and possesses similar but less potent inhibitory activity. Inhibits TRP channels independently of PLA₂, including TRPM2, TRPC6 and TRPM8. It is a useful tool for studying the physiological role of TRP channels.

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Product Details

Alternative Name	ACA
Appearance	White solid.
CAS	110683-10-8
Couple Target	Phospholipase, TRP channel
Couple Type	Blocker, Inhibitor
Formula	C₂₁H₂₃NO₃
MW	337.4
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO (50 mg/ml) or ethanol (50 mg/ml @ 60°C).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Make solutions fresh daily.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress: Zou, L., Collins, H. E., et al.; Front. Mol. Biosci. 8, 780865 (2021), Abstract
Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators: Y. Song, et al.; J. Biomol. Screen. 13, 54 (2008), Abstract
N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker: C. Hartenec, et al.; Cardiovasc. Drug Rev. 25, 61 (2007), Abstract
Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid: R. Kraft, et al.; Br. J. Pharmacol. 148, 264 (2006), Abstract — Full Text
Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid: P. Thams & K. Capito; Biochem. Pharmacol. 53, 1077 (1997), Abstract
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H. S. Banga, et al.; Proc. Natl. Acad. Sci. USA 83, 9197 (1986), Abstract — Full Text

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N-(p-Amylcinnamoyl)anthranilic acid

BML-EI178

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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