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N-Desmethyl Clozapine

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Serotonin receptor ligand

Major metabolite of clozapine. Potent serotonin 5-HT_1c receptor antagonist.

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Alternative Name	Norclozapine
Appearance	Yellow solid.
CAS	6104-71-8
Couple Target	Serotonin receptor
Couple Type	Ligand
Formula	C₁₇H₁₇ClN₄
Identity	Determined by 1H-NMR.
MW	312.8
Purity	≥99% (HPLC)
Solubility	Soluble in ethanol (25 mg/ml) or DMSO (>44 mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract — Full Text
Metabolism and bioactivation of clozapine by human liver in vitro: M. Pirmohamed, et al.; J. Pharmacol. Exp. Ther. 272, 984 (1995), Abstract
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors: B.L. Roth, et al.; J. Pharmacol. Exp. Ther. 268, 1403 (1994), Abstract
On-line fully automated determination of clozapine and desmethylclozapine in human serum by solid-phase extraction on exchangeable cartridges and liquid chromatography using a methanol buffer mobile phase on unmodified silica: O.V. Olesen & B. Poulsen; J. Chromatog. 622, 39 (1993), Abstract
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993), Abstract

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