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N-Arachidonylglycine

BML-FA029

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FAAH inhibitor

Endogenous anandamide-like compound. Lacks affinity for CB₁ receptors (Ki>10µM), TRPV1 (EC₅₀>10µM) and anandamide uptake (IC₅₀>50µM), but inhibits fatty acid amide hydrolase (FAAH) (IC₅₀=8.5µM-50µM, depending on cell type and species). Displays anti-inflammatory and analgesic activity. Identified as an insulin secretagogue in a primary β-cell-based functional assay. Represents a new class of “lipoamino acids”.

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Product Details

Appearance	White waxy solid.
CAS	179113-91-8
Couple Target	FAAH
Couple Type	Inhibitor
Formula	C₂₂H₃₅NO₃
MW	361.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO or 100% ethanol. 2mg/ml soluble in PBS (pH 7.2).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from air.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.: D. McHugh, et al.; BMC Neurosci. 11, 44 (2010), Abstract
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18: M. Kohno, et al.; BBRC 347, 827 (2006), Abstract
A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase: M. Grazia Cascio, et al.; BBRC 314, 192 (2004), Abstract
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain: S.M. Huang, et al.; J. Biol. Chem. 276, 42639 (2001), Abstract
Oxidative metabolism of anandamide: S.H. Burstein, et al.; Prostaglandins Other Lipid Mediat. 61, 29 (2000), Abstract
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor: T. Sheskin, et al.; J. Med. Chem. 40, 659 (1997), Abstract

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N-Arachidonylglycine

BML-FA029

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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