Home Shop N-Acetyl-S-geranylgeranyl-L-cysteine

N-Acetyl-S-geranylgeranyl-L-cysteine

BML-G220

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Blocks methyl esterification of geranylgeranylated proteins

AGGC specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. AGGC blocks receptor-mediated signal transduction in human neutrophils (IC₅₀=4 µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A and inhibits β2-integrin-induced actin polymerization (IC₅₀~45 nM) in neutrophils.

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Product Details

Appearance	Yellow viscous oil.
CAS	139332-94-8
Couple Target	Methyltransferase
Couple Type	Inhibitor
Formula	C₂₅H₄₁NO₃S
MW	435.7
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibitors of farnesyl and geranylgeranyl methyltransferases prevent beta 2 integrin-induced actin polymerization without affecting beta 2 integrin-induced Ca2+ signaling in neutrophils: L. Molony, et al.; Biochem. Biophys. Res. Commun. 223, 612 (1996), Abstract
Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide: R. Regazzi, et al.; Biochim. Biophys. Acta 1268, 269 (1995), Abstract
Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils: M.R. Philips, et al.; Science 259, 977 (1993), Abstract
A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues: C. Volker, et al.; FEBS Lett. 295, 189 (1991), Abstract

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N-Acetyl-S-geranylgeranyl-L-cysteine

BML-G220

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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