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N-Acetyl-leukotriene E4

BML-LEA004

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Major bilary metabolite of cysteinyl leukotrienes in the rat. Approximately 100-fold less active than LTC₄. Equiactive with LTE₄ in guinea pig lung parenchyma assay.

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Product Details

Alternative Name	N-Acetyl-LTE4
Appearance	Liquid.
CAS	80115-95-3
Couple Target	Leukotriene receptor, Prostanoid receptor
Couple Type	Ligand
Formula	C₂₅H₃₉NO₆S
Formulation	Solution in ethanol.
MW	481.7
Purity	≥98% (HPLC)
Solubility	Soluble in ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -80°C for up to 1 year.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Pharmacological profile of leukotrienes E4, N-acetyl E4 and of four of their novel omega- and beta-oxidative metabolites in airways of guinea-pig and man in vitro: M.N. Samhoun, et al.; Br. J. Pharmacol. 98, 1406 (1989), Abstract — Full Text
Identification of the major endogenous leukotriene metabolite in the bile of rats as N-acetyl leukotriene E4: W. Hagmann, et al.; Prostaglandins 31, 239 (1986), Abstract
The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig: A. Foster, et al.; Prostaglandins 31, 1077 (1986), Abstract
Production of peptide leukotrienes in endotoxin shock: W. Hagmann, et al.; FEBS Lett. 180, 309 (1985), Abstract
Leukotrienes as mediators in tissue trauma: C. Denzlinger, et al.; Science 230, 330 (1985), Abstract

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N-Acetyl-leukotriene E4

BML-LEA004

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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