Home Shop N-Acetyl-Asp-Glu-OH

N-Acetyl-Asp-Glu-OH

ALX-151-020

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Glutamate receptor ligand

Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.

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Product Details

Alternative Name	α-NAAG, Spaglumic acid
Appearance	White to off-white powder.
CAS	3106-85-2
Formula	C₁₁H₁₆N₂O₈
MW	304.3
Purity	≥98% (TLC)
Solubility	Soluble in water and methanol (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

N-acetylaspartylglutamate in Canavan disease: an adverse effector?: A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999), Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998), Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998), Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997), Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997), Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer’s diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997), Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997), Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997), Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997), Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996), Abstract

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N-Acetyl-Asp-Glu-OH

ALX-151-020

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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