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N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde

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Cathepsin-L inhibitor

Potent, selective and reversible inhibitor of human cathepsin L (IC₅₀=1.9nM). Inhibits release of Ca²⁺ and hydroxyproline from bone in vitro.

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Alternative Name	N-(1Naphthalenylsulfonyl)- IW-CHO
Appearance	White to off-white powder.
CAS	161709-56-4
Formula	C₂₇H₂₉N₃O₄S
MW	491.6
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO or ethyl acetate (50mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells: D. Chauss, et al.; Nat. Immunol. 23, 62 (2022), Abstract
Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor: T. Jiang, et al.; NPJ Parkinsons Dis. 8, 127 (2022), Abstract
An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19: McGregor, R., Chauss, D., et al.; bioRxiv , (2020)
Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells: Kolev, M., West, E. E., et al.; Immunity 52, 513 (2020), Abstract
The protease cathepsin L regulates Th17 cell differentiation: L. Hou, et al.; J. Autoimmun. 65, 56 (2015), Application(s): Cell Culture, Abstract
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice: T. Wartmann, et al.; Gastroenterology 138, 726 (2010), Abstract — Full Text
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption: T. Yasuma, et al.; J. Med. Chem. 41, 4301 (1998), Abstract

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