Home Shop N-ω-Propyl-L-arginine

N-ω-Propyl-L-arginine

ALX-270-203

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nNOS inhibitor

Potent and selective inhibitor of neuronal nitric oxide synthase (nNOS; NOS I) relative to inducible nitric oxide synthase (iNOS; NOS II) (3158-fold) and endothelial nitric oxide synthase (eNOS; NOS III) (149-fold).

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Product Details

Alternative Name	N5-[Imino(propylamino)methyl]-L-ornithine
Appearance	White to off-white solid.
CAS	137361-05-8
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₉H₂₀N₄O₂
MW	216.3
Purity	≥98% (TLC)
Solubility	Soluble in PBS, pH 7.2 (25mg/ml), 100% ethanol (10mg/ml), DMSO (50μg/ml) or dimethyl formamide (50μg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least one year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle: C. Gowda, et al.; Nitric Oxide 11, 17 (2004), Abstract
The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice: D. Klamer, et al.; Eur. J. Pharmacol. 503, 103 (2004), Abstract
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem. 278, 45818 (2003), Abstract — Full Text
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000), Abstract — Full Text
Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform: G.R. Cooper, et al.; Arch. Biochem. Biophys. 375, 183 (2000), Abstract
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases: Y. Lee, et al.; Bioorg. Med. Chem. 7, 1097 (1999), Abstract
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase: H. Huang, et al.; J. Med. Chem. 42, 3147 (1999), Abstract
Potent and selective inhibition of neuronal nitric oxide synthase by N-omega-propyl-L-arginine: H.Q. Zhang, et al.; J. Med. Chem. 40, 3869 (1997), Abstract
Mechanism of inactivation of neuronal nitric oxide synthase by N-allyl-L-arginine: H.Q. Zhang, et al.; JACS 119, 10888 (1997)

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N-ω-Propyl-L-arginine

ALX-270-203

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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