Myriocin

BML-SL226

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Palmitoyltransferase inhibitor

Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. BML-A195). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (K_i=0.28nM), therefore useful as a tool to deplete cells of sphingolipids. Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC₅₀=15nM).

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Product Details

Alternative Name	ISP-1, Thermozymocidin, 2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid
Appearance	White to off-white solid.
CAS	35891-70-4
Couple Target	Palmitoyltransferase
Couple Type	Inhibitor
Formula	C₂₁H₃₉NO₆
MW	401.5
Purity	≥98% (TLC)
RTECS	JX3890000
Solubility	Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy: P.P. Laurila, et al.; Sci. Adv. 8, eabh4423 (2022), Abstract
Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment: C. Hu, et al.; Microbial Spectr. 10, e0012722 (2022), Abstract
Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga: Ziv, C., Malitsky, S., et al.; PNAS 113, E1907 (2016), Abstract
ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner: Y. Zhao; J. Lipid Res. 56, 644 (2015), Application(s): Cell Culture, Abstract — Full Text
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis: Martínez, L., Torres, S., et al.; Oncotarget 6, 41479 (2015), Abstract
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse: Cheng, J. C., Bai, A., et al.; J. Clin. Invest. 123, 4344 (2013), Abstract
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model: T. Umehara, et al.; BBRC 346, 67 (2006), Abstract
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice: M.R. Hojjati, et al.; J. Biol. Chem. 280, 10284 (2005), Abstract
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast: Y. Sun, et al.; Mol. Cell. Biol. 20, 4411 (2000), Abstract — Full Text
Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells: S. Furuya, et al.; J. Neurochem. 71, 366 (1998), Abstract

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Myriocin

BML-SL226

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