Myricetin

ALX-385-012

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Chemopreventive agent

Antioxidant flavonoid. Has antitumor and chemopreventive properties. Anti-inflammatory. Inhibits NF-κB activation.
PIM1 kinase inhibitor IC₅₀=0.78µM.

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Product Details

Alternative Name	3,3′,4′,5,5′,7-Hexahydroxyflavone
Appearance	Light yellow-green crystals.
CAS	529-44-2
Couple Target	NF-kappaB
Couple Type	Inhibitor
Formula	C₁₅H₁₀O₈
MI	14: 6332
MW	318.2
Purity	≥90% (HPLC)
RTECS	LK8646000
Solubility	Soluble in alcohol; slightly soluble in water (warm); insoluble in acetic acid.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity: B. LaFoya, et al.; PLoS One 14, e0210607 (2019), Abstract — Full Text
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1: K.W. Lee, et al.; Carcinogenesis 28, 1918 (2007), Abstract
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase: S. Holder, et al.; Mol. Cancer Ther. 6, 163 (2007), Abstract
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity: J. Lu, et al.; Cancer Res. 66, 4410 (2006), Abstract
Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells: C.H. Ko, et al.; Mol. Cancer Ther. 4, 281 (2005), Abstract
Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade: C.H. Ko, et al.; Biochem. Pharmacol. 69, 913 (2005), Abstract
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001), Abstract
Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells: S. H. Tsai, et al.; J. Cell Biochem. 74, 606 (1999), Abstract
Biological effects of myricetin: K. C. Ong & H. E. Khoo; Gen. Pharmacol. 29, 121 (1997), (Review), Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med. 20, 933 (1996), (Review), Abstract

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Myricetin

ALX-385-012

Product Details

Handling & Storage

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