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Mycophenolic acid

BML-A249

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Inosine-5’-monophosphate dehydrogenase inhibitor

Antiviral and immunosuppressive activity. Clinically useful antipsoriatic agent. Mycophenolic acid prodrugs are effective in rheumatoid arthritis and for the prevention of organ transplant rejection. Mechanism of action is inhibition of inosine-5′-monophosphate dehydrogenase.

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Product Details

Alternative Name	6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexanoic acid
Appearance	White solid.
CAS	24280-93-1
Couple Target	Inosine-5’-monophosphate dehydrogenase
Couple Type	Inhibitor
Formula	C₁₇H₂₀O₆
MW	320.3
Purity	≥98% (HPLC)
RTECS	MP8050000
Solubility	Soluble in DMSO (clear colorless solution at 50 mg/ml) or 100% ethanol.
Source	Isolated from Penicillium brevi-compactum

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil: A. C Allison et al.; Immunol. Rev. 136, 5 (1993), Abstract
Therapy of rheumatoid arthritis with mycophenolate mofetil: R. Goldblum; Clin. Exp. Rheumatol. 11 Suppl 8, S117 (1993), Abstract
The use of mycophenolate mofetil (RS-61443) in human heart transplant recipients: R.D. Ensley et al.; Transplantation 56, 75 (1993), Abstract
Mycophenolic acid for psoriasis. A review of pharmacology, long-term efficacy, and safety: W.W. Epinette et al.; J. Am. Acad. Dermatol. 17, 962 (1987), Abstract

Last modified: May 29, 2024

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Mycophenolic acid

BML-A249

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Handling & Storage

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