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Mycalolide B

BML-T123

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Depolymerizes actin

Mycalolide B is a novel marine natural product which binds to actin in a 1:1 molar ratio (K_d=13-20 nM). It selectively and completely depolymerizes F-actin to G-actin via a mechanism distinct from that of the cytochalasins. Unlike cytochalasins, it inhibits actin-activated Mg²⁺-ATPase from rabbit skeletal muscle.

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Product Details

Appearance	Clear to white solid
CAS	122752-21-0
Couple Target	ATPase
Couple Type	Inhibitor
Formula	C₅₂H₇₄N₄O₁₇
MW	1027.2
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, methanol or isopropanol
Source	Isolated from the marine sponge Mycale sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Cancer cells suppress NK activity by actin-driven polarisation of inhibitory ligands at the synapse: Hoffmann, C., Filali, L., et al.; bioRxiv , (2025)
Toxoplasma gondii-Induced Neutrophil Extracellular Traps Amplify the Innate and Adaptive Response: F.J.B. Miranda, et al.; Mbio 12, e0130721 (2021), Abstract
TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis: J.M. Varberg, et al.; Mbio. 9, e00301-18 (2018), Abstract — Full Text
Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection: Lima, T. S., Gov, L., et al.; Mbio 9, (2018), Abstract
Nuclear herpesvirus capsid motility is not dependent on F-actin: J.B. Bosse, et al.; MBio 5, e01909 (2014), Abstract — Full Text
Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication: Niedelman, W., Sprokholt, J. K., et al.; Infect. Immun. 81, 4341 (2013), Abstract
Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15: Gov, L., Karimzadeh, A., et al.; Mbio 4, (2013), Abstract
Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells: H. Sasaki et al.; Biochem. Biophys. Res. Commun. 316, 588 (2004), Abstract
Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B: R. Takakuwa; Exp. Cell. Res. 257, 238 (2000), Abstract
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. 123, 571 (1998), Abstract

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Last modified: May 29, 2024

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Mycalolide B

BML-T123

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