Mycalolide B is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM). It selectively and completely depolymerizes F-actin to G-actin via a mechanism distinct from that of the cytochalasins. Unlike cytochalasins, it inhibits actin-activated Mg2+-ATPase from rabbit skeletal muscle.
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RUO – Research Use Only |
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