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Mu-Phe-hPhe-FMK

BML-EI323

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Cathepsin inhibitor

Irreversible, non-toxic, cell-permeable inhibitor of cysteine proteases calpain, cathepsins B and L, and Trypanosome trypanopain. Can be used in vitro (typically 20 µM) or in vivo. Inhibits tumor formation and growth.

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Product Details

Alternative Name	N-Morpholineurea-phenylalanyl-homophenylalanylfluoromethyl ketone
Appearance	White solid.
Formula	C₂₅H₃₀FN₃O₄
MW	455.5
Purity	≥98% (TLC)
Sequence	Mu-Phe-hPhe-FMK
Solubility	Soluble in DMSO (>25 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at 4°C for up to 1 year. Store DMSO concentrates at -20°C for up to 1 year. Do not store dilute solutions.
Long Term Storage	+4°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers: L. A. Couto, et al.; J. Neurosci. Res. 77, 410 (2004), Abstract
Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei: V. P. Triggs & J. D. Bangs; Eukaryot. Cell. 2, 76 (2003), Abstract — Full Text
Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B: C. J. F. Van Noorden, et al.; Clin. Exp. Metastasis 16, 159 (1998), Abstract
Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo: M.M. Wasilewski, et al.; Mol. Biochem. Parasitol. 81, 179 (1996), Abstract
The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design: J.H. McKerrow, et al.; Parasitol. Today 11, 279 (1995), Abstract
Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis: R. E. Esser, et al.; Arthritis Rheum. 37, 236 (1994), Abstract
Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts: C. J. F. Van Noorden & V. Everts; Biochem. Biophys. Res. Commun. 178, 178 (1991), Abstract

Last modified: May 29, 2024

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Mu-Phe-hPhe-FMK

BML-EI323

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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