MTEP

ALX-550-381

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mGluR5 antagonist

Potent and highly selective antagonist for mGluR5 with a 5-fold higher anxiolytic activity than MPEP (Prod. No. ALX-550-368). Shows fewer off-target effects than MPEP.

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Product Details

Appearance	White to yellow solid.
CAS	329205-68-7
Couple Target	Metabotropic glutamate receptor
Couple Type	Inhibitor, Ligand
Formula	C₁₁H₈N₂S
MW	200.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, 100% ethanol or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP): M.D. Green, et al.; Neurosci. Lett. 391, 91 (2006), Abstract
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors: P.M.t. Lea, et al.; Br. J. Pharmacol. 145, 527 (2005), Abstract
MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats: K. Ossowska, et al.; Neuropharmacology 49, 447 (2005), Abstract
Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist: A. Palucha, et al.; Pharmacol. Biochem. Behav. 81, 901 (2005), Abstract
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling: A. Klodzinska, et al.; Neuropharmacology 47, 342 (2004), Abstract
[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor: N.D. Cosford, et al.; Bioorg. Med. Chem. Lett. 13, 351 (2003), Abstract
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization: J.J. Anderson, et al.; J. Pharmacol. Exp. Ther. 303, 1044 (2002), Abstract
Reduced stress-induced hyperthermia in mGluR5 knockout mice: J. Brodkin, et al.; Eur. J. Neurosci. 16, 2241 (2002), Abstract

Related Products

MPEP . hydrochloride

ALX-550-368

mGluR5 antagonist

13 citations

Alternative Name	6-Methyl-2-(phenylethynyl)-pyridine . HCl
CAS	96206-92-7
Couple Type	Inhibitor, Ligand
Purity	≥99%

Last modified: May 29, 2024

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MTEP

ALX-550-381

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