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Product Details
| Alternative Name |
Multidrug resistance-associated protein 4, ABCC4 |
|---|---|
| Application |
ICC, IHC (FS), WB |
| Application Notes |
Immunocytochemistry: cytospin preparations |
| Clone |
M4I-10 |
| Formulation |
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
| Host |
Rat |
| Immunogen |
Recombinant human MRP4 (multidrug resistance-associated protein 4) (aa 372-431). |
| Isotype |
IgG2a |
| Recommendation Dilutions/Conditions |
Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with biotin-labelled rabbit anti-rat IgG and HRP-labelled streptavidin.Western Blot: Use 1:20-1:50 dilution and HRP-anti-rat-IgG.Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human, Mouse |
| UniProt ID |
O15439 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Short Term Storage |
+4°C |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo: Murray, J., Valli, E., et al.; Eur. J. Cancer 83, 132 (2017), Abstract
- Regulation of PDZ domain-containing 1 (PDZK1) expression by hepatocyte nuclear factor-1α (HNF1α) in human kidney: Prestin, K., Hussner, J., et al.; Am. J. Physiol. Renal Physiol. 313, F973 (2017), Abstract
- N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity: M.F. Miah, et al.; Biochem. Biophys. Res. Commun. 469, 954 (2016), Application(s): Immunoblotting, Abstract
- Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate: K. Sayyed, et al.; Toxicology 363, 58 (2016), Application(s): Cell culture; Effects on ABC transporter activities, Abstract
- Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4): Csandl, M. A., Conseil, G., et al.; Drug Metab. Dispos. 44, 857 (2016), Abstract
- Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines.: Diez, F., Davio, C., et al.; PLoS One 10, e0120651 (2015), Application(s): WB, Abstract
- Aromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer: Khatri, R., Shah, P., et al.; Mol. Cancer Ther. 14, 1728 (2015), Abstract
- Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport: Jin, D., Ni, T. T., et al.; Nat. Cell Biol. 16, 841 (2014), Abstract
- ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux: Henderson, M. J., Haber, M., et al.; J. Natl. Cancer Inst. 103, 1236 (2011), Abstract
- Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin: Marquez, B., Ameye, G., et al.; PLoS One 6, e28368 (2011), Abstract
- Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells: Porro, A., Haber, M., et al.; J. Biol. Chem. 285, 19532 (2010), Abstract
- Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4: Hirouchi, M., Kusuhara, H., et al.; Drug Metab. Dispos. 37, 2103 (2009), Abstract
- Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver: Lee, J. K., Abe, K., et al.; Drug Metab. Dispos. 37, 1916 (2009), Abstract
- Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells: Marquez, B., Caceres, N. E., et al.; Antimicrob. Agents Chemother. 53, 2410 (2009), Abstract
- Down-regulation of Na+/H+ Exchanger Regulatory Factor 1 Increases Expression and Function of Multidrug Resistance Protein 4: M.T. Hoque & S.P. Cole; Cancer Res. 68, 4802 (2008), Abstract — Full Text
- Immunohistochemical detection of multidrug-resistant protein expression in retinoblastoma treated by primary enucleation: Wilson, M. W., Fraga, C. H., et al.; Invest. Ophthalmol. Vis. Sci. 47, 1269 (2006), Abstract
- Mrp4 confers resistance to topotecan and protects the brain from chemotherapy: M. Leggas, et al.; Mol. Cell. Biol. 24, 7612 (2004), Abstract
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