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Product Details
| Alternative Name |
Multidrug resistance-associated protein 2, cMOAT, ABCC2 |
|---|---|
| Application |
ICC, IHC (FS), IHC (PS), WB |
| Clone |
M2III-6 |
| Crossreactivity |
Does not cross-react with human P-glycoprotein, MDR3, MRP1, MRP3 or MRP5. |
| Formulation |
Liquid. In PBS containing 0.1% BSA and 0.02% sodium azide. |
| Host |
Mouse |
| Immunogen |
Recombinant C-terminal rat MRP2 (multidrug resistance-associated protein-2; cMOAT) (aa 1339-1541). |
| Isotype |
IgG2a |
| Recommendation Dilutions/Conditions |
Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.Immunohistochemistry (frozen sections) (1:20): Can be use on acetone fixed frozen sections. Can be followed by incubation with rabbit anti-mouse antibody and a monoclonal mouse APAAP complex.Immunohistochemistry (paraffin sections) (1:20, weak): Can be used on formaldehyde-fixed paraffin-embedded tissues and tumors, after pretreatment with 0.01M citric acid (pH 6.0) in distilled water at 100°C for 5 min 3 times. After incubation with the primary antibody and washing, slides can be incubated with biotinylated rabbit anti-mouse antibody and streptavidin conjugated to horseradish peroxidase.Western Blot: Use 1:20-1:50 and anti-mouse HRP.Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human, Rat |
| Specificity |
Recognizes an internal epitope of MRP2. |
| UniProt ID |
Q63120 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Handling |
Avoid freeze/thaw cycles. |
|---|---|
| Short Term Storage |
+4°C |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants: Kölz, C., Gaugaz, F. Z., et al.; Br. J. Pharmacol. 181, 4593 (2024), Abstract
- Extracellular Vesicles as Surrogates for the Regulation of the Drug Transporters ABCC2 (MRP2) and ABCG2 (BCRP): J.P. Rigalli, et al.; Int. J. Mol. Sci. 25, 4118 (2024), Abstract
- A microfluidic thyroid-liver platform to assess chemical safety in humans: J. Kühnlenz, et al.; ALTEX 40, 61 (2023), Abstract
- Galectin-1 confers resistance to doxorubicin in hepatocellular carcinoma cells through modulation of P-glycoprotein expression: P. Carabias, et al.; Cell Death Discov. 13, 239 (2022), Abstract
- Iron overload reduces synthesis and elimination of bile acids in rat liver: A. Prasnicka, et al.; Sci. Rep. 9, 9780 (2019), Abstract — Full Text
- Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress: F.D. Toledo, et al.; Arch. Toxicol. 91, 2391 (2017), Abstract
- Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation: P. Ellinger, et al.; World J. Gastroenterol. 23, 5295 (2017), Application(s): Immunofluorescence staining of liver samples, Abstract — Full Text
- Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate: K. Sayyed, et al.; Toxicology 363, 58 (2016), Application(s): Cell culture; Effects on ABC transporter activities, Abstract
- Analysis of the Bile Salt Export Pump (ABCB11) Interactome Employing Complementary Approaches: S. Przybylla, et al.; PLoS One 11, e0159778 (2016), Application(s): Immunofluorescence staining of liver cryosections and differentiated HepaRG cells, Abstract — Full Text
- Exon-skipping and mRNA decay in human liver tissue: molecular consequences of pathogenic bile salt export pump mutations: C. Droge, et al.; Sci. Rep. 6, 24827 (2016), Application(s): Immunofluorescence of liver tissue, Abstract
- The antitripanocide benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2): J.P. Rigalli, et al.; Toxicol. Appl. Pharmacol. 304, 90 (2016), Application(s): Western blot, Abstract
- Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson’s disease mouse model: H. Li, et al.; J. Ethnopharmacol. 176, 336 (2015), Application(s): Western blot, Abstract
- Coordinated induction of GST and MRP2 by cAMP in Caco-2 cells: Role of protein kinase A signaling pathway and toxicological relevance: M.R. Arana, et al.; Toxicol. Appl. Pharmacol. 287, 178 (2015), Application(s): Cell culture , Abstract
- Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy: C. Luna-Tortos, et al.; Neuropharmacology 58, 1019 (2010), Abstract
- Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells: S. Lowes, et al.; Br. J. Pharmacol. 135, 1263 (2002), Abstract — Full Text
- Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract — Full Text
- Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2: J.H. Hooijberg, et al.; Cancer Res. 59, 2532 (1999), Abstract — Full Text
- Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA: R. Evers, et al.; J. Clin. Invest. 101, 1310 (1998), Abstract — Full Text
- Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene: C.C. Paulusma, et al.; Science 271, 1126 (1996), Abstract
Last modified: May 29, 2024
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