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Product Details
| Alternative Name |
Multidrug resistance-associated protein 2, cMOAT, ABCC2 |
|---|---|
| Application |
ICC, IHC (FS), WB |
| Application Notes |
Immunohistochemistry: Suitable for frozen sections, weak in paraffin sections. |
| Clone |
M2I-4 |
| Crossreactivity |
Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP3 or MRP5. Does not cross-react with mouse, rat or guinea pig MRP2. |
| Formulation |
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
| Host |
Mouse |
| Immunogen |
Recombinant human MRP2 (multidrug resistance-associated protein 2; cMOAT) (aa 215-310). |
| Isotype |
IgG1 |
| Recommendation Dilutions/Conditions |
Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.Immunohistochemistry (frozen sections): Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. Or, after incubation with the primary antibody and washing, slides can be incubated with biotinylated rabbit anti-mouse IgG and streptavidin conjugated to horseradish peroxidase.Western Blot: Use 1:20-1:50 dilution and anti-mouse-HRP.Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human |
| Specificity |
Recognizes an internal epitope of human MRP2. |
| UniProt ID |
Q92887 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Short Term Storage |
+4°C |
|---|---|
| Long Term Storage |
+4°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Autoantibody formation against a canalicular epitope found in a patient with acute intrahepatic cholestasis with PFIC-like presentation: Schumacher, J., Herta, T., et al.; JHEP Rep. 4, 100418 (2022), Abstract
- Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1: Nasr, R., Lorendeau, D., et al.; Sci. Rep. 10, 7616 (2020), Abstract
- Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models: V. Vauthier, et al.; Sci. Rep. 9, 6653 (2019), Abstract — Full Text
- Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation: P. Ellinger, et al.; World J. Gastroenterol. 23, 5295 (2017), Application(s): Immunofluorescence staining of liver samples, Abstract — Full Text
- Functional Defect of Variants in the ATP-binding Sites of ABCB4 and their Rescue by the CFTR Potentiator, Ivacaftor (VX-770): J. Delaunay, et al.; Hepatology 65, 560 (2017), Abstract
- Exon-skipping and mRNA decay in human liver tissue: molecular consequences of pathogenic bile salt export pump mutations: C. Droge, et al.; Sci. Rep. 6, 24827 (2016), Application(s): Immunofluorescence of liver tissue, Abstract
- Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4): Csandl, M. A., Conseil, G., et al.; Drug Metab. Dispos. 44, 857 (2016), Abstract
- Utilization of arsenic trioxide as a treatment of cisplatin-resistant non-small cell lung cancer PC-9/CDDP and PC-14/CDDP cells.: Nishio, K., Ishibashi, K., et al.; Oncol. Lett. 10, 805 (2015), Application(s): WB / Reactant(s): Human, Abstract
- Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract — Full Text
Last modified: May 29, 2024
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