Home Shop MRP1 (human) monoclonal antibody (QCRL-1)

MRP1 (human) monoclonal antibody (QCRL-1)

ALX-801-010

16 citations

Datasheet
Manual
SDS
CofA

Already have an account?

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

This antibody is covered by our Worry-Free Guarantee.

QCRL-1 and MRPm6 epitopes. The model shown is only one of several possible configurations. MSD=membrane spanning domain; NBD=nucleotide binding domain. From R. Hipfner — **Figure**: Human MRP1-specific MAb QCRL-1 (Prod.No. ALX-801-010).”””,MRP1 (human) monoclonal antibody (QCRL-1) image,MRP1 (human) monoclonal antibody (QCRL-1) image,yes
ALX-801-013,801-013.gif,http://static.enzolifesciences.com/fileadmin/files/image/801-013.gif,**Figure:** Epitope Mapping of MAbs MRPr1

Product Details

Alternative Name	Multidrug resistance-associated protein 1, ABCC1
Application	Flow Cytometry, ICC, IHC (PS), IP, WB
Application Notes	Flow Cytometry: cell permeabilization required Immunocytochemistry: cytospin preparations
Clone	QCRL-1
Crossreactivity	Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP5, or mouse MRP gene products.
Formulation	Liquid. 0.22μm-filtered solution in PBS containing 0.7% BSA and 0.1% sodium azide.
Host	Mouse
Immunogen	Membranes prepared from the human small cell lung cancer cell line H69AR.
Isotype	IgG1
Recommendation Dilutions/Conditions	Flow Cytometry (1:20)Immunocytochemistry (1:20-1:50)Western Blot (0.02-0.2µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human
Specificity	Recognizes the linear internal epitope (S⁹¹⁸SYSGDI⁹²⁴) of human MRP1 (multidrug resistance-associated protein 1), overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
UniProt ID	P33527
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion: Whitt, J. D., Keeton, A. B., et al.; J. Biomed. Res. 30, 120 (2016), Abstract
Utilization of arsenic trioxide as a treatment of cisplatin-resistant non-small cell lung cancer PC-9/CDDP and PC-14/CDDP cells.: Nishio, K., Ishibashi, K., et al.; Oncol. Lett. 10, 805 (2015), Application(s): WB / Reactant(s): Human, Abstract
cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter: Biondi, C., Ferretti, M. E., et al.; Mol. Hum. Reprod. 16, 481 (2010), Abstract
Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux: Morrow, C. S., Peklak-Scott, C., et al.; Mol. Pharmacol. 69, 1499 (2006), Abstract
Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000), Abstract
The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000), Abstract
MRP expression in acute myeloid leukemia. An update: M. Filipits, et al.; Adv. Exp. Med. Biol. 457, 141 (1999), Abstract
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier: V.V. Rao, et al.; PNAS 96, 3900 (1999), Abstract — Full Text
Expression of the multidrug resistance protein (MRP1) in breast cancer: M. Filipits, et al.; Anticancer Res. 19, 5043 (1999), Abstract
ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells: Q. Mao, et al.; Biochim. Biophys. Acta 1461, 69 (1999), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

MRP1 (human) monoclonal antibody (QCRL-1)

ALX-801-010

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project