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Product Details
| Alternative Name |
Multidrug resistance-associated protein 1, ABCC1 |
|---|---|
| Application |
Flow Cytometry, ICC, IHC (FS), WB |
| Application Notes |
Flow Cytometry: cell permeabilization required |
| Clone |
MRPm6 |
| Crossreactivity |
Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP5. |
| Formulation |
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
| Host |
Mouse |
| Immunogen |
Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 1294-1531). |
| Isotype |
IgG1 |
| Recommendation Dilutions/Conditions |
Suggested starting dilution is 1:20Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human |
| Specificity |
Recognizes the internal epitope (P1511SDLLQQRGL1520) of human MRP1. |
| UniProt ID |
P33527 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Short Term Storage |
+4°C |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1: Nasr, R., Lorendeau, D., et al.; Sci. Rep. 10, 7616 (2020), Abstract
- Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1: L. Dury, et al.; Biochem. Pharmacol. 124, 10 (2017), Application(s): Western blot, BHK-21 cells, Abstract
- Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β: E. Roundhill, et al.; FASEB J. 30, 1712 (2016), Application(s): WB / Reactant(s) Human, Abstract
- Flow cytometric assessment of P-glycoprotein and multidrug resistance-associated protein activity and expression in canine lymphoma: B. Pozniak, et al.; In Vivo 29, 149 (2015), Abstract
- Dimethyl sulfoxide induces chemotherapeutic resistance in the treatment of testicular embryonal carcinomas: H. Kita, et al.; Oncol. Lett. 10, 661 (2015), Application(s): Western blot, Abstract — Full Text
- Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy: C. Luna-Tortos, et al.; Neuropharmacology 58, 1019 (2010), Abstract
- Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer: Owatari, S., Akune, S., et al.; Cancer Res. 67, 4860 (2007), Abstract
- (R)- and (S)-Verapamil Differentially Modulate the Multidrug-resistant Protein MRP1: T. Perrotton, et al.; J. Biol. Chem. 282, 31542 (2007), Abstract — Full Text
- Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state: Zhang, D. W., Gu, H. M., et al.; J. Biol. Chem. 278, 46052 (2003), Abstract
- Expression of the multidrug resistance-associated protein in myelodysplastic syndromes: S. Poulain, et al.; Br. J. Haematol. 110, 591 (2000), Abstract
- Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart: A. Rosati, et al.; Anticancer Res. 20, 3403 (2000), Abstract
- The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000), Abstract
- Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000), Abstract
- Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract — Full Text
- Evidence for the involvement of the glutathione pathway in drug resistance in AML: J.M. Sargent, et al.; Adv. Exp. Med. Biol. 457, 205 (1999), Abstract
- Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis: G.A. Meijer, et al.; J. Clin. Pathol. 52, 450 (1999), Abstract
- Overexpression of lung-resistance protein and increased P-glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival: A.G. Borg, et al.; Br. J. Haematol. 103, 1083 (1998), Abstract
- Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP): D.R. Hipfner, et al.; Br. J. Cancer 78, 1134 (1998), Abstract
- Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia 11, 1078 (1997), Abstract
- Tissue distribution of the multidrug resistance protein: M.J. Flens, et al.; Am. J. Pathol. 148, 1237 (1996), Abstract
- Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer: K. Nooter, et al.; Ann. Oncol. 7, 75 (1996), Abstract
- Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995), Abstract
- Expression of the multidrug resistance-associated protein (MRP) gene in human cancers: K. Nooter, et al.; Clin. Cancer Res. 1, 1301 (1995), Abstract
- The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump: G.J. Zaman, et al.; PNAS 91, 8822 (1994), Abstract — Full Text
- Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies: M.J. Flens, et al.; Cancer Res. 54, 4557 (1994), Abstract
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