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MPEP . hydrochloride

ALX-550-368

13 citations

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mGluR5 antagonist

Potent and selective antagonist for mGluR5 receptor. Systemically active in vivo.

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Product Details

Alternative Name	6-Methyl-2-(phenylethynyl)-pyridine . HCl
Appearance	Off-white powder.
CAS	96206-92-7
Couple Target	Metabotropic glutamate receptor
Couple Type	Inhibitor, Ligand
Formula	C₁₄H₁₁N . HCl
Identity	Determined by NMR.
MW	193.3 . 36.5
Purity	≥99%
Solubility	Soluble in water, DMSO or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Tet controls axon guidance in early brain development through glutamatergic signaling: Tran, H., Le, L., et al.; iScience 27, 109634 (2024), Abstract
Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson’s disease: M.R. Domenici, et al.; J. Neurosci. Res. 80, 646 (2005), Abstract
Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats: M. Pietraszek, et al.; Eur. J. Pharmacol. 514, 25 (2005), Abstract
In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling: J.M. Wieronska, et al.; Neuropsychopharmacology 29, 514 (2004), Abstract — Full Text
Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo: C.A. Heidbreder, et al.; Synapse 50, 269 (2003), Abstract
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist: E. Tatarczynska, et al.; Br. J. Pharmacol. 132, 1423 (2001), Abstract — Full Text
Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence: L.S. Thomas, et al.; Neuropharmacology 41, 523 (2001), Abstract
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective: V. Bruno, et al.; Neuropharmacology 39, 2223 (2000), Abstract
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893): A.G. Chapman, et al.; Neuropharmacology 39, 1567 (2000), Abstract
Methylphenylethynylpyridine (MPEP) Novartis: F. Micheli; Curr. Opin. Investig. Drugs 1, 355 (2000), Abstract

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MPEP . hydrochloride

ALX-550-368

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