Monophosphoryl Lipid A from E. coli, Serotype R515 (Re) (TLRGRADE®) (Ready-to-Use)

Activates TLR4 (Toll-like receptor 4). Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice. Exhibits reduced endotoxic and pyrogenic activity compared to lipid A and LPS.

MPL-A from E. coli, Serotype R515 (Re)

TLR, TLR4

Activator, Ligand

Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.

≥99.9% (regarding protein or DNA contaminants; KDO not detectable)

Isolated from E. coli, Serotype R515 (Re mutant). Prepared by acid hydrolysis from purified E. coli, Serotype R515 (Re) LPS (isolated by a modification of the PCP extraction method), converted to the uniform salt form and dissolved in sterile pyrogen-free double distilled water.