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Monoclonal antibody to Transglutaminase 2

NZY-A037

Axxora Marketplace
  • NZY-A037-200   —   200 µg
    $880.00

Tissue transglutaminase is a Ca2+-dependent enzyme (78kDa) composed by 4 domains: beta-Sheet Domain (fibronectin binding, ~17kDa), catalytic Core Domain (Cys-His-Asp catalytic triad, Calcium-binding, GTP/GDP-binding, ~37kDa), beta-Barrel 1 Domain (GTP/GDP-binding, ~14kDa) and beta-Barrel 2 Domain (~12kDa). The inactive GTP-bound enzyme is present in a closed conformation, which upon activation by Ca2+ and substrate binding opens like a pocket knife resulting in a longitudinal open conformation.

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Regulatory Status

RUO – Research Use Only