Monastrol

BML-GR322

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Kinesin inhibitor

Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC₅₀=14µM) by binding to the mitotic kinesin Eg5.

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Product Details

Alternative Name	4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
Appearance	White to light yellow solid.
CAS	329689-23-8
Couple Target	Kinesin
Couple Type	Inhibitor
Formula	C₁₄H₁₆N₂O₃S
MW	292.4
MeltingPoint	184-186°C
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (20mg/ml) or 100% ethanol (4mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome: C.J. Sieben, et al.; J. Clin. Invest. 130, 171 (2020), Abstract — Full Text
Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524: A.P. Baron, et al.; eLife 5, e12187 (2016), Application(s): Cell culture, Abstract
Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis: Wike, C. L., Graves, H. K., et al.; Elife 5, e11402 (2016), Abstract
Cytokinetic failure-induced tetraploidy develops into aneuploidy, triggering skin aging in phospho-vimentin deficient mice: H. Tanaka, et al.; J. Biol. Chem. 290, 12984 (2015), Application(s): Cell Culture using mouse fibroblasts, Abstract — Full Text
Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One 8, e72886 (2013), Abstract — Full Text
Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein: T. Peters, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 372, 291 (2006), Abstract
A pathway of structural changes produced by monastrol binding to Eg5: Z. Maliga, et al.; J. Biol. Chem. 281, 7977 (2006), Abstract
Allosteric inhibition of kinesin-5 modulates its processive directional motility: B.H. Kwok, et al.; Nat. Chem. Biol. 2, 480 (2006), Abstract
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures: S.Y. Yoon, et al.; Cell Motil. Cytoskeleton 60, 181 (2005), Abstract
Inhibition of a mitotic motor protein: where, how, and conformational consequences: Y. Yan, et al.; J. Mol. Biol. 335, 547 (2004), Abstract

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Monastrol

BML-GR322

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