Home Shop MnTMPyP . pentachloride

MnTMPyP . pentachloride

ALX-430-070

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SOD mimetic. Peroxynitrite scavenger.

Cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Catalyzes the dismutation of O₂^– even in the presence of excess EDTA. Displays a protective effect against H₂O₂ mediated injury in astroglial cells.

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Product Details

Appearance	Black crystalline powder.
Formula	C₄₄H₃₆MnN₈Cl₅
MW	909.0
Purity	≥95% (TLC)
Solubility	Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Prepare fresh solutions daily, immediately prior to use
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

HIV-1 Gag Blocks Selenite-Induced Stress Granule Assembly by Altering the mRNA Cap-Binding Complex: A. Cinti, et al.; MBio 7, e00329 (2016), Application(s): Cell culture, Abstract — Full Text
CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia: Makarenko, V. V., Ahmmed, G. U., et al.; J. Neurophysiol. 115, 345 (2016), Abstract
H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea: Yuan, G., Peng, Y. J., et al.; Sci. Signal. 9, ra80 (2016), Abstract
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure: A.A. Miller, et al.; Br. J. Pharmacol. 131, 29 (2000), Abstract
SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells: R. Morandini, et al.; Cell. Mol. Biol. (Noisy-le-grand) 45, 1053 (1999), Abstract
Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta: A. MacKenzie, et al.; Br. J. Pharmacol. 127, 1159 (1999), Abstract
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol. 53, 795 (1998), Abstract
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem. 273, 24521 (1998), Abstract — Full Text
Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys. 325, 20 (1996), Abstract
A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli: S.I. Liochev & I. Fridovich; Arch. Biochem. Biophys. 321, 271 (1995), Abstract

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MnTMPyP . pentachloride

ALX-430-070

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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