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MMP substrate (fluorogenic)

BML-P128

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Fluorogenic substrate for several matrix metalloproteinases (MMPs). It is cleaved by MMP-1, MMP-3, MMP-7, MMP-8, MMP-9, MMP-11, MMP-12, MMP-13, and ADAM9/MDC9, but only slightly by MMP-2 and not at all by ADAM17/TACE. Ex/Em= 340nm/440nm, although 365/450 is also appropriate. Highly quenched, with strong fluorescence by Nma at 440nm once cleavage separates it from the aromatic Dnp moiety. Compatible with most fluorometers.

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Product Details

Alternative Name	Matrix metalloproteinase substrate, Dnp-Pro-β-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(Nma)-NH2
Appearance	lyophylized solid
MW	1077.4
Purity	≥98% (HPLC)
Sequence	Dnp-P(Cha)G(CMe)HA(KNma)-amide
Solubility	Soluble in DMSO (at least 20mM).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Chemical Composition and Effect against Skin Alterations of Bioactive Extracts Obtained by the Hydrodistillation of Eucalyptus globulus Leaves: P. Moreira, et al.; Pharmaceutics 14, 561 (2022), Abstract
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid: A. Drieu, et al.; Nature 611, 585 (2022), Abstract
Polyphenol-Rich Extracts Obtained from Winemaking Waste Streams as Natural Ingredients with Cosmeceutical Potential: M.S. Matos, et al.; Antioxidants 8, 355 (2019), Application(s): Substrate in MMP-1 activity assays., Abstract — Full Text
Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane: D.W. Barrett, et al.; Sci. Rep. 9, 6718 (2019), Abstract — Full Text
Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity: T. Duellman, et al.; Biochem. J. 475, 1597 (2018), Abstract — Full Text
Toll-Like Receptor 4-Independent Carbon Tetrachloride-Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice: Role of Hepatic Stellate Cells: S. Kumar, et al.; Am. J. Pathol. 187, 1356 (2017), Abstract — Full Text
The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity: M.J. Mohan, et al.; Biochemistry 41, 9462 (2002), Abstract
N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)’, and S(2)’ pockets: S. Hanessian, et al.; J. Med. Chem. 44, 3066 (2001), Abstract
Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity: M. Roghani, et al.; J. Biol. Chem. 274, 3531 (1999), Abstract
Detection system for reaction-rate analysis in a low-volume proteinase-inhibition assay: W.P. Ambrose, et al.; Anal. Biochem. 263, 150 (1998), Abstract

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MMP substrate (fluorogenic)

BML-P128

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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