ML-9

BML-EI153

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Myelin basic protein inhibitor

Selective inhibitor of MLC kinase (K_i=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC₅₀=10-50 µM). Also known to inhibit PKA (IC₅₀=20 µM) and S6 kinase (IC₅₀=50 µM). Does not inhibit PI 3-kinase.

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Product Details

Alternative Name	1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
Appearance	White solid.
CAS	105637-50-1
Couple Target	Akt, MLCK, PKA, S6 kinase
Couple Type	Inhibitor
Formula	C₁₅H₁₇N₂O₂SCl . HCl
Identity	Determined by 1H-NMR and MS.
MW	361.3
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml) and ethanol/water (1:1, 10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Additive effects of low concentrations of estradiol-17β and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways: Y. Pang & P. Thomas; J. Steroid Biochem. Mol. Biol. 165, 258 (2017), Application(s): Involvement of kinase signaling pathways in stimulation of NO production, Abstract
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes: U. Smith, et al.; Biochem. Biophys. Res. Commun. 268, 315 (2000), Abstract
Stimulation of protein phosphatase-1 activity by insulin in rat adipocytes. Evaluation of the role of mitogen-activated protein kinase pathway: N. Begum; J. Biol. Chem. 270, 709 (1995), Abstract
Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells: J.A. Reig, et al.; Neurochem. Res. 18, 317 (1993), Abstract
Effects of ML-9 on insulin stimulation of glucose transport in 3T3-L1 adipocytes: G. Inoue, et al.; J. Biol. Chem. 268, 5272 (1993), Abstract
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle: M. Seto, et al.; Eur. J. Pharmacol. 195, 267 (1991), Abstract
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells: T. Nagatsu, et al.; Biochem. Biophys. Res. Commun. 143, 1045 (1987), Abstract
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem. 262, 7796 (1987), Abstract
The modulatory role of myosin light chain phosphorylation in human platelet activation: M. Saitoh, et al.; Biochem. Biophys. Res. Commun. 140, 280 (1986), Abstract

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Last modified: May 29, 2024

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ML-9

BML-EI153

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