Home Shop ML-7 . HCl

ML-7 . HCl

BML-EI197

Datasheet
Manual
SDS
CofA

Already have an account?

Protein kinase inhibitor

Potent and selective inhibitor of MLC kinase (K_i=0.3 µM). It inhibts also smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA).

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
Appearance	White solid.
CAS	110448-33-4
Couple Target	MLCK, PKA, PKC
Couple Type	Inhibitor
Formula	C₁₅H₁₇IN₂O₂S·HCl
MW	452.7
Purity	≥99%
Solubility	Soluble in DMSO (10mg/ml), ethanol/water (1:1, 10mg/ml), 100% ethanol (warm) and methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Excitable Rho dynamics control cell shape and motility by sequentially activating ERM proteins and actomyosin contractility: Marshall-Burghardt, S., Migueles-Ramírez, R. A., et al.; Sci. Adv. 10, eadn6858 (2024), Abstract
Single-pericyte nanomechanics measured by contraction cytometry: Islam, M. M., Gaska, I., et al.; APL Bioeng. 8, 036109 (2024), Abstract
Excitable Rho dynamics drive cell contractions by sequentially inducing ERM protein-mediated actin-membrane attachment and actomyosin contractility: Marshall-Burghardt, S., Migueles-Ramírez, R. A., et al.; bioRxiv , (2023)
LAP2β transmits force to upregulate genes via chromatin domain stretching but not compression: J. Sun, et al.; Acta Biomater. , (2021), Abstract
Physical basis for the determination of lumen shape in a simple epithelium: C.G. Vasquez, et al.; Nat. Commun. 12, 5608 (2021), Abstract
Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy: C.W. Hsieh, et al.; Nat. Commun. 10, 969 (2019), Application(s): added during cell culture to screen for functional and structrual changes in mitophagy in HeLa cells expressing EBFP-2-Parkin, EGFP-dMito and KillerRed-dMito, Abstract — Full Text
Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells: B. Xuan, et al.; Sci. Rep. 8, 11935 (2018), Abstract
A cdk1 gradient guides surface contraction waves in oocytes: Bischof, J., Brand, C. A., et al.; Nat. Commun. 8, 849 (2017), Abstract
Caffeine inhibits migration in glioma cells through the ROCK-FAK pathway: Chen, Y., Chou, W. C., et al.; Cell. Physiol. Biochem. 33, 1888 (2014), Abstract
Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity: Luo, C., Gangadharan, V., et al.; PLoS Biol. 10, e1001283 (2012), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

ML-7 . HCl

BML-EI197

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project