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mito-TEMPO-H

ALX-430-171

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Spin probe

Spin probe for detection of mitochondrial superoxide.
Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.

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Product Details

Alternative Name	1-hydroxy-4-[2-triphenylphosphonio)-acetamido]-2,2,6,6-tetramethylpiperidine, 1-Hydroxy-2,2,6,6-tetramethyl-4-[2-(triphenylphosphonio)acetamido]piperidinium dichloride
Appearance	Colorless to pink.
Application Notes	Mito-TEMPO-H can be used for superoxide detection.
Formula	C₂₉H₃₇N₂O₂Cl₂P . H₂O
MW	511.1 . 18.0
Purity	≥95% (EPR)
Solubility	Soluble in water, 100% ethanol or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action: B.M. Pharoah, et al.; Redox Biol. 60, 102625 (2023), Abstract
Mitochondrial Hydrogen Peroxide Activates PTEN and Inactivates Akt Leading to Autophagy Inhibition-Dependent Cell Death in Neuronal Models of Parkinson’s Disease: Yu, Q., Zhang, R., et al.; Mol. Neurobiol. 60, 3345 (2023), Abstract
Only IL-1β release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted: E. Korhonen, et al.; FASEB J. 34, 6437 (2020), Abstract — Full Text
Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K: H.B. Eajaili, et al.; J. Vis. Exp. , e58461 (2019), Abstract
Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response: H. Liu, et al.; Cardiovasc. Res. 103, 131 (2014), Abstract — Full Text
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines: S.I. Dikalov, et al.; Free Rad. Res. 45, 417 (2011), Abstract
Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract

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mito-TEMPO-H

ALX-430-171

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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