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Mitochondria-targeted antioxidant
Mitochondria-targeted antioxidant with superoxide and alkyl radical scavenging properties, which may be used for both in vivo and in vitro experiments.
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Product Details
| Alternative Name |
(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride |
|---|---|
| Appearance |
Colorless film to pale orange solid. |
| CAS |
1334850-99-5 |
| Formula |
C29H35N2O2ClP |
| Identity |
Determined by MS. |
| MW |
510.03 |
| Purity |
≥95% (TLC) |
| Solubility |
Soluble in water, DMSO, 100% ethanol or methanol. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Solutions in water, saline, ethanol or DMSO are stable at +4°C for 1-2 weeks. DMSO stock solution can be stored also at -20°C. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Myeloid DRP1 deficiency limits revascularization in ischemic muscles via inflammatory macrophage polarization and metabolic reprogramming: Yadav, S., Ganta, V. C., et al.; JCI Insight 10, (2025), Abstract
- Mineralocorticoid receptor promotes cardiac macrophage inflammaging: Fraccarollo, D., Geffers, R., et al.; Basic Res. Cardiol. 119, 243 (2024), Abstract
- Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis via pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension: Liu, L., Pang, W., et al.; J. Transl. Int. Med. 12, 437 (2024), Abstract
- Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase: T.D. Pham, et al.; Am. J. Physiol. Renal Physiol. 326, F202 (2024), Abstract
- Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro: Shrivastava, G., Valenzuela-Leon, P. C., et al.; iScience 27, 108620 (2024), Abstract
- Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia: Tang, Y., Wu, J., et al.; Cell Rep. 43, 114237 (2024), Abstract
- Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet’s syndrome: Konaka, H., Kato, Y., et al.; EMBO J. 42, e112573 (2023), Abstract
- Protective role of hydrogen sulfide against diabetic cardiomyopathy via alleviating necroptosis: W. Gong, et al.; Free Radic. Biol. Med. 181, 29 (2022), Abstract
- Aldosterone Suppresses Endothelial Mitochondria through Mineralocorticoid Receptor/Mitochondrial Reactive Oxygen Species Pathway: S.Y. Peng, et al.; Biomedicines 10, 1119 (2022), Abstract
- P66Shc-mediated reactive oxygen species and autophagy disrupts brain microvascular endothelial cell function in response to hyperglycemia: Wang, L., Yang, M., et al.; Research Square , (2022)
- Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts: Jung, Y. H., Chae, C. W., et al.; J. Biomed. Sci. 29, 17 (2022), Abstract
- Neonatal Hyperoxia Activates ATF4 to Stimulate Folate Metabolism and AT2 Cell Proliferation: M. Yee, et al.; Am. J. Respir. Cell Mol. Biol. , (2022), Abstract
- Targeting mitochondrial permeability transition pore ameliorates PM 2.5-induced mitochondrial dysfunction in airway epithelial cells: Y. Liang, et al.; Environ. Pollut. 295, 118720 (2022), Abstract
- Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome: L.Q. Wang, et al.; Nat. Commun. 12, 2915 (2021), Abstract — Full Text
- i>O/i>-GlcNAcylation, oxidation and CaMKII contribute to atrial fibrillation in type 1 and type 2 diabetes by distinct mechanisms: Mesubi, O. O., Rokita, A. G., et al.; bioRxiv , (2020)
- Toll interacting protein protects bronchial epithelial cells from bleomycin-induced apoptosis: Li, X., Kim, S. E., et al.; FASEB J. 34, 9884 (2020), Abstract
- Chlamydia pneumoniae infection-induced endoplasmic reticulum stress causes fatty acid-binding protein 4 secretion in murine adipocytes: Walenna, N. F., Kurihara, Y., et al.; J. Biol. Chem. 295, 2713 (2020), Abstract
- Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency: Luciani, A., Schumann, A., et al.; Nat. Commun. 11, 970 (2020), Abstract
- Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner: Brinker, A. E., Vivian, C. J., et al.; Cancer Res. 80, 1118 (2020), Abstract
- CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction: E. Aplak, et al.; PLoS One 15, e0227926 (2020), Abstract — Full Text
- MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation: J. Zheng, et al.; Cell Death Dis. 11, 256 (2020), Abstract — Full Text
- Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress: M. Sonavane, et al.; PLoS One 15, e0242174 (2020), Abstract — Full Text
- Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells: F. De Santis, et al.; PLoS One 14, e0213150 (2019), Abstract — Full Text
- Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics: J. Nomura, et al.; Sci. Rep. 9, 17314 (2019), Abstract — Full Text
- Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease: G. Renga, et al.; Life Sci. Alliance 2, e201900432 (2019), Abstract — Full Text
- Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR: Deng, M., Guo, H., et al.; J. Exp. Med. 216, 2838 (2019), Abstract
- Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia: Yu, H., Alruwaili, N., et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 317, L569 (2019), Abstract
- ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation: E. Park, et al.; Cell Death Dis. 10, 822 (2019), Abstract — Full Text
- Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney: Festa, B. P., Chen, Z., et al.; Nat. Commun. 9, 161 (2018), Abstract
- Mitochondria-targeted antioxidant MitoTEMPO improves the post-thaw sperm quality: X. Lu, et al.; Cryobiology 80, 26 (2018), Abstract
- Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia: Vaka, V. R., McMaster, K. M., et al.; Hypertension 72, 703 (2018), Abstract
- Sestrin2 facilitates glutamine-dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation: Kumar, A., Giri, S., et al.; FEBS J. 285, 1326 (2018), Abstract
- Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport: Zou, L., Linck, V., et al.; J. Biol. Chem. 293, 1666 (2018), Abstract
- SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation: A. Kumar & C. Shaha; Sci. Rep. 8, 615 (2018), Abstract — Full Text
- Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence: Tezze, C., Romanello, V., et al.; Cell Metab. 25, 1374 (2017), Abstract
- Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility: H. Qi, et al.; Diabetes 66, 763 (2017), Abstract — Full Text
- Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia: Nagai, H., Satomi, T., et al.; EBioMedicine 24, 147 (2017), Abstract
- Ionizing Radiation Induces Innate Immune Responses in Macrophages by Generation of Mitochondrial Reactive Oxygen Species: S. Kim, et al.; Radiat Res. 187, 32 (2017), Abstract
- NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes: Freeman, L., Guo, H., et al.; J. Exp. Med. 214, 1351 (2017), Abstract
- Induction of Lipotoxic Brain Microvascular Injury is Mediated by Activating Transcription Factor 3-Dependent Inflammatory and Oxidative Stress Pathways: H.H. Aung, et al.; J. Lipid Res. 57, 955 (2016), Application(s): Cell culture, Abstract — Full Text
- NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages: Moon, J. S., Nakahira, K., et al.; Nat. Med. 22, 1002 (2016), Abstract
- Therapeutically targeting mitochondrial redox signalling alleviates endothelial dysfunction in preeclampsia: C. McCarthy & L.C. Kenny; Sci. Rep. 6, 32683 (2016), Application(s): Mitochondrial-targeted antioxidant capacity assays in HUVEC , Abstract — Full Text
- Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation: Lee, Y., Byun, H. S., et al.; Sci. Rep. 6, 25094 (2016), Abstract
- MAVS maintains mitochondrial homeostasis via autophagy: X. Sun, et al.; Cell Discov. 2, 16024 (2016), Application(s): Cell culture, Abstract — Full Text
- Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A: C. Xu, et al.; Neuropharmacology 105, 270 (2016), Application(s): Cell culture, Abstract
- Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes: Lee, H., Kang, S. W., et al.; PLoS One 10, e0136122 (2015), Abstract
- Krüppel-like factor 6 regulates mitochondrial function in the kidney: S.K. Mallipattu, et al.; J. Clin. Invest. 125, 1347 (2015), Abstract — Full Text
- Metabolic regulation of the ultradian oscillator Hes1 by Reactive Oxygen Species: S. Ventre, et al.; J. Mol. Biol. 2015, 1887 (2015), Application(s): Cell Culture, Abstract
- Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation: W.K. Ip, et al.; Nat. Commun. 6, 6931 (2015), Application(s): Cell Culture, Abstract
- Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy: Jabir, M. S., Hopkins, L., et al.; Autophagy 11, 166 (2015), Abstract
- Mitochondrial function provides instructive signals for activation-induced B-cell fates: Jang, K. J., Mano, H., et al.; Nat. Commun. 6, 6750 (2015), Abstract
- HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation: S.J. Han, et al.; Cell. Death Dis. 6, e1863 (2015), Application(s): In vivo, Abstract — Full Text
- Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy: R. Ni, et al.; Free Radic. Biol. Med. 90, 12 (2015), Application(s): Cell culture in diabetic mice, Abstract
- Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity: Lo Verso, F., Carnio, S., et al.; Autophagy 10, 1883 (2014), Abstract
- Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes: Q. He, et al.; Oxid. Med. Cell. Longev. 2014, 654198 (2014), Application(s): Detection of cellular and mitochondrial ROS levels, Mito-Tempo effect on tafazzin knockdown, Abstract — Full Text
- Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury: N.K. Patil, et al.; Am. J. Physiol. Renal. Physiol. 306, 34 (2014), Application(s): Injection, Abstract — Full Text
- Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes: Lee, H. M., Kim, J. J., et al.; Diabetes 62, 194 (2013), Abstract
- TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway: J.D. Schilling, et al.; J. Immunol. 190, 1285 (2013), Application(s): Mitochondria-targeted antioxidant in macrophages, Abstract — Full Text
- Angiotensin II-induced production of mitochondrial ROS: Potential mechanisms and relevance for cardiovascular disease: S.I. Dikalov & R.R. Nazarewicz; Antioxid. Redox Signal. 19, 1085 (2013), Abstract — Full Text
- The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis: Z. Wang, et al.; PLoS One 8, e75044 (2013), Application(s): Flow Cytometry, Western Blotting, Detection of cellular and mitochondrial ROS levels, Abstract — Full Text
- Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis: Zhang, T., Li, Y., et al.; Autophagy 8, 559 (2012), Abstract
- Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation: C. Juliana, et al.; J. Biol. Chem. 287, 36617 (2012), Application(s): Immunoblotting, Abstract — Full Text
- Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel: M. Liu, et al.; Circ. Res. 107, 967 (2010), Abstract — Full Text
- SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery: H.L. Liang, et al.; Free Rad. Biol. Med. 49, 1550 (2010), Abstract
- Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract
- Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells: H.L. Liang, et al.; Apoptosis 14, 1176 (2009), Abstract
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