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Mithramycin A

BML-GR305

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Transcription inhibitor

Mithramycin noncovalently interacts with G-C-rich duplex DNA in the presence of Mg²⁺ or Zn²⁺. It induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression. It selectively inhibits collagen-1 gene expression in human fibroblasts.

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Product Details

Alternative Name	Plicamycin
Appearance	Yellow solid.
CAS	18378-89-7
Formula	C₅₂H₇₆O₂₄
MI	14: 7536
MW	1085.1
Purity	≥95% (HPLC, TLC)
Solubility	Soluble in phosphate buffered saline (1mg/ml), 100% ethanol, DMSO or methanol
Source	Isolated from Streptomyces argillaceus

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization: Gomes, A. P., Ilter, D., et al.; Cancer Cell 36, 402 (2019), Abstract
Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells: E. Im, et al.; Life Sci. 192, 286 (2018), Abstract
Early activation of Egr-1 promotes neuroinflammation and dopaminergic neurodegeneration in an experimental model of Parkinson’s disease: Q. Yu, et al.; Exp. Neurol. 302, 145 (2018), Abstract
AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo: Wang, X., Li, K., et al.; Sci. Rep. 5, 13542 (2015), Abstract
Mithramycin A activates Fas death pathway in leukemic cell lines: I. Leroy, et al.; Apoptosis 11, 113 (2006), Abstract
Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression: S.Y. Ahn, et al.; Am. J. Pathol. 164, 1663 (2004), Abstract
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3: M.A. Mir, et al.; Bioorg. Med. Chem. 11, 2791 (2003), Abstract
Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast: M.C. Nehls, et al.; J. Clin. Invest. 92, 2916 (1993), Abstract
Interaction of mithramycin with DNA. Evidence that mithramycin binds to DNA as a dimer in a right-handed screw conformation: C. Demicheli, et al.; Eur. J. Biochem. 198, 333 (1991), Abstract
Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene: R. Ray, et al.; Am. J. Med. Sci. 300, 203 (1990), Abstract

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Mithramycin A

BML-GR305

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