Minoxidil

BML-KC125

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K⁺ channel activator

A selective ATP-sensitive K⁺ (K_ATP) channel opener. It is metabolized to the more active sulfate in vivo. A clinically useful anti-alopecia. Antihypertensive. Stimulates renin secretion. Potent vascular smooth muscle relaxant.

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Product Details

Alternative Name	U-10858
Appearance	White solid.
CAS	38304-91-5
Couple Target	Potassium channel
Couple Type	Activator
Formula	C₉H₁₅N₅O
MI	14: 6203
MW	209.3
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol (29mg/ml), DMSO (6.5mg/ml) or water (2.2mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Possible presence of the ATP-sensitive K+ channel in isolated spinal dorsal horn neurons of the rat: S. Yamashita, et al.; Neurosci. Lett. 170, 208 (1994), Abstract
Potassium channel conductance as a control mechanism in hair follicles: A.E. Buhl, et al.; J. Invest. Dermatol. 101, 148S (1993), Abstract
Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil: K.D. Meisheri, et al.; Biochem. Pharmacol. 45, 271 (1993), Abstract
Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts: T. Hautala, et al.; Biochem. J. 283, 51 (1992), Abstract
Chapter 20. Pathogenesis and Treatment of Alopecias: R.C. Gadwood & V.C. Fiedler; Ann. Rep. Med. Chem. 24, 187 (1989)
Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability: K.D. Meisheri, et al.; J. Pharmacol. Exp. Ther. 245, 751 (1988), Abstract
Minoxidil: a review of its pharmacological properties and therapeutic use: V.M. Campese; Drugs 22, 257 (1981), Abstract

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Minoxidil

BML-KC125

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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