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Milrinone

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PDE3 inhibitor

Selective inhibitor of phosphodiesterase 3 (PDE3, IC₅₀=0.3µM).

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Alternative Name	1,6-Dihydro-2-methyl-6-oxo-3,4′-bipyridine-5-carbonitrile
Appearance	White to light red solid.
CAS	78415-72-2
Couple Target	PDE
Couple Type	Inhibitor
Formula	C₁₂H₉N₃O
MI	14: 6197
MW	211.2
Purity	≥97% (HPLC)
RTECS	DW1762000
Solubility	Soluble in DMSO (20mg/ml) or warm 100% ethanol (3mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit: Tenner, B., Getz, M., et al.; Elife 9, (2020), Abstract
AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA: Clister, T., Greenwald, E. C., et al.; Cell Chem. Biol. 26, 885 (2019), Abstract
Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery: J.M. Bailey, et al.; Anesthesiology 81, 616 (1994), Abstract
In vitro pharmacology of R 80122, a novel phosphodiesterase inhibitor: D. Wilhelm, et al.; J. Cardiovasc. Pharmacol. 20, 705 (1992), Abstract
Bemoradan–a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol. 42, 679 (1991), Abstract
Effects of isozyme-selective phosphodiesterase inhibitors on rat aorta and human platelets: smooth muscle tone, platelet aggregation and cAMP levels: S.H. Lindgren, et al.; Acta Physiol. Scand. 140, 209 (1990), Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989), Abstract
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs: S.A. Harrison, et al.; Mol. Pharmacol. 29, 506 (1986), Abstract

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