Skip to main content

Microcystin-LW

ALX-350-080

34 citations

  • ALX-350-080-M001   —   1 mg
    $4,000.00
  • ALX-350-080-C025   —   25 µg
    $295.00
  • ALX-350-080-C100   —   100 µg
    $643.00
  • Potent inhibitor of PP1 and PP2A
  • Used in biochemical studies in intact cells
  • Cited in several environment-related research articles

Microcystin-LW (MC-LW) is an analog of microcystin-LR (Prod. No. ALX-350-012) with Trp substituted in place of Arg. MC-LW is hydrophobic and more cell permeable than other microcystins. This increased cell permeability can be useful for biochemical studies in intact cells. MC-LW has a characteristically different absorption spectrum compared to other microcystins, making it a useful reference compound for HPLC analysis. The Trp confers an absorption maximum at 222nm, whereas most microcystins have a characteristic maximum at 239nm.

May require a license for import, please contact us for more information.

Cyanobacteria are photosynthetic prokaryotes mostly present in freshwater ecosystems. The increasingly frequent appearance of cyanobacteria blooms in lakes and rivers is linked to climate changes and human activities. Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account


Regulatory Status

RUO – Research Use Only