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Key inhibitor for use in proteasome research.
- High purity peptide
- Most economical MG-132 on the market
- Widely cited for more than two decades
- Well-characterized with a variety of applications
MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0.85 and 0.1μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.
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Product Details
| Alternative Name |
Z-LLL-CHO |
|---|---|
| Appearance |
White solid. |
| CAS |
133407-82-6 |
| Formula |
C26H41N3O5 |
| MW |
475.6 |
| Purity |
≥98% |
| Sequence |
Z-Leu-Leu-Leu-CHO |
| Solubility |
Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
| Technical Info / Product Notes |
Replacement for ADI-HPK-116</strong |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Solutions are stable for up to one week if stored at -20°C. Solutions are stable for up to two months if stored at -80°C. |
|---|---|
| Long Term Storage |
-80°C |
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- SEL1L-HRD1 ER-Associated Degradation Facilitates Prohormone Convertase 2 Maturation and Glucagon Production in Islet α Cells: W. Zhu, et al.; bioRxiv , 2025.03.20.644437 (2025), Abstract
- USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity: Dai, P., Sun, Y., et al.; Nat. Commun. 16, 4564 (2025), Abstract
- Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer: J. Namkaew, et al.; Cancer Lett. 582, 216509 (2024), Abstract
- The ubiquitin-proteasome pathway inhibitor TAK-243 has major effects on calcium handling in mammalian cells: X. Gao, et al.; Biochim. Biophys. Acta Mol. Cell Res. 1871, 119618 (2024), Abstract
- Oligomerization and a distinct tRNA-binding loop are important regulators of human arginyl-transferase function: X. Lan, et al.; Nat. Commun. 15, 6350 (2024), Abstract
- Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAPdeficient inflammatory bowel disease: J. Lee, et al.; Sci. Rep. 14, 853 (2024), Abstract
- Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties: Prus, G., Satpathy, S., et al.; Cell 187, 2875 (2024), Abstract
- LRP10 and α-synuclein transmission in Lewy body diseases: Carreras Mascaro, A., Grochowska, M. M., et al.; Cell. Mol. Life Sci. 81, 75 (2024), Reactant(s): Human, Abstract
- Mitochondrial fatty acid oxidation drives senescence: Yamauchi, S., Sugiura, Y., et al.; Sci. Adv. 10, eado5887 (2024), Abstract
- p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus: Oikawa, T., Hasegawa, J., et al.; Life Sci. Alliance 7, (2024), Abstract
- Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy: Hutchings, A. J., Hambrecht, B., et al.; Nat. Commun. 15, 8622 (2024), Abstract
- Ubiquiton-An inducible, linkage-specific polyubiquitylation tool: Renz, C., Asimaki, E., et al.; Mol. Cell 84, 386 (2024), Abstract
- Differential processing of RNA polymerase II at DNA damage correlates with transcription-coupled repair syndrome severity: Gonzalo-Hansen, C., Steurer, B., et al.; Nucleic Acids Res. 52, 9596 (2024), Abstract
- Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge: C.M. Schafer, et al.; bioRxiv , 2023.02.08.527788 (2023), Abstract
- 14-3-3 proteins regulate cullin 7-mediated Eag1 degradation: C.H. Hsieh, et al.; Cell Biosci. 13, 18 (2023), Abstract
- ARD1 stabilizes NRF2 through direct interaction and promotes colon cancer progression: X. Gang, et al.; Life Sci. 313, 121217 (2023), Abstract
- Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication: S. Krieg, et al.; Cell. Mol. Life Sci. 80, 72 (2023), Abstract
- SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD: L. Griewahn, et al.; Cell Rep. 42, 111961 (2023), Abstract
- SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1: D. Wang, et al.; Cell Death Differ. 30, 369 (2023), Abstract
- Zika Virus Induces the Degradation of the Numb Protein that is Required through Embryonic Neurogenesis: J. He, et al.; Viruses 15, 1258 (2023), Abstract
- Inflammation-induced TRIM21 represses hepatic steatosis by promoting the ubiquitination of lipogenic regulators: K.C. Nikolaou, et al.; JCI Insight 8, e164694 (2023), Abstract
- pH-Responsive, Charge-Reversing Layer-by-Layer Nanoparticle Surfaces Enhance Biofilm Penetration and Eradication: E.D. Yehiely, et al.; ACS Biomater. Sci. Eng. 9, 4794 (2023), Abstract
- A comprehensive atlas of the aging vertebrate brain reveals signatures of progressive proteostasis dysfunction: Fraia, D. D., Marino, A., et al.; bioRxiv , (2023)
- A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas: Cervia, L. D., Shibue, T., et al.; Cancer Discov. 13, 766 (2023), Abstract
- Bacterial lipopolysaccharide inhibits colonic carrier-mediated uptake of thiamin pyrophosphate: roles for TLR4 receptor and NF-κB/P38/JNK signaling pathway: Selvaraj, A., Sabui, S., et al.; Am. J. Physiol. Cell Physiol. 325, C758 (2023), Abstract
- Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction: Kim, M. J., Serwa, R. A., et al.; Nat. Commun. 14, 4092 (2023), Reactant(s): Human, Abstract
- LRP10 as a novel α-synuclein regulator in Lewy body diseases: Mascaro, A. C., Grochowska, M. M., et al.; bioRxiv , (2023), Reactant(s): Human
- p53 secures the normal behavior of H3.1 histone in the nucleus by regulating nuclear phosphatidic acid and EZH2 during the G1/S phase: Oikawa, T., Hasegawa, J., et al.; bioRxiv , (2023)
- PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability: Fevga, C., Tesson, C., et al.; Brain 146, 1496 (2023), Abstract
- Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity: Tsai, C. L., Yang, P. S., et al.; J. Clin. Transl. Hepatol. 11, 614 (2023), Abstract
- Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens: A. Nelde, et al.; Cell. Mol. Life Sci. 79, 171 (2022), Abstract
- Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass: S. Wegmann, et al.; Mol. Cell 82, 1589 (2022), Abstract
- Bladder cancer cell lines adapt their aggressiveness profile to oxygen tensio: S. Chabaud, et al.; Oncol. Lett. 24, 220 (2022), Abstract
- Dinaciclib inhibits the stemness of two subtypes of human breast cancer cells by targeting the FoxM1 and Hedgehog signaling pathway: A.N. Tsao, et al.; Oncol. Rep. 47, 105 (2022), Reactant(s): Human, Abstract
- Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring: V.L. Tzounakas, et al.; Redox Biol. 57, 102477 (2022), Abstract
- Using reporters of different misfolded proteins reveals differential strategies in processing protein aggregates: K.L. Schneider, et al.; J. Biol. Chem. 298, 102476 (2022), Abstract
- Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS: Günther, R., Pal, A., et al.; Cells 11, (2022), Reactant(s): Human, Abstract
- AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway: Kothari, V., Babu, J. R., et al.; PLoS One 17, e0266472 (2022), Abstract
- Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast Cancer: Jehanno, C., Le Goff, P., et al.; Cancers (Basel) 14, (2022), Abstract
- The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells: Palanivel, C., Chaudhary, N., et al.; Neoplasia 25, 28 (2022), Abstract
- USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy: Xiong, W., Gao, X., et al.; Nat. Commun. 13, 1700 (2022), Abstract
- Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer: W.K. Lee, et al.; Int. J. Mol. Med. 31, 101492 (2021), Abstract
- Interplay between protein acetylation and ubiquitination controls MCL1 protein stability: K. Shimizu, et al.; Cell Rep. 37, 109988 (2021), Abstract
- Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation: S. Jeong, et al.; Pharmaceuticals 14, 1092 (2021), Abstract
- The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson’s disease is promoted by conserved oxidation sites: M.W. Baeken, et al.; Cell Death Discov. 7, 286 (2021), Abstract
- Protein kinase D, ubiquitin and proteasome pathways are involved in adenosine receptor-stimulated NR4A expression in myeloid cells: H.E. Giffney, et al.; Biochem. Biophys. Res. Commun. 555, 19 (2021), Abstract
- An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control: F. Eisele, et al.; Cell Rep. 35, 109328 (2021), Abstract
- Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans: M. Sladowska, et al.; PLoS Biol. 19, e3001302 (2021), Abstract
- VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma: A. Ganner, et al.; Sci. Rep. 11, 41598 (2021), Abstract
- Aromatic monophenols from cinnamon bark act as proteasome inhibitors by upregulating ER stress, suppressing FoxM1 expression, and inducing apoptosis in prostate cancer cells: S. Gopalakrishnan, et al.; Phytother. Res. 35, 5781 (2021), Abstract
- Red Blood Cell Proteasome in Beta-Thalassemia Trait: Topology of Activity and Networking in Blood Bank Conditions: A.T. Anastasiadi, et al.; Membranes 11, 716 (2021), Abstract
- The Effect of Neddylation Blockade on Slug-Dependent Cancer Cell Migration Is Regulated by p53 Mutation Status: Y. Kim, et al.; Cancers 13, 531 (2021), Abstract
- Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins: Nowicka, U., Chroscicki, P., et al.; Elife 10, (2021), Abstract
- Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer: Dang, F., Nie, L., et al.; Nat. Commun. 12, 5386 (2021), Abstract
- Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage: Ait-Ammar, A., Bellefroid, M., et al.; Sci. Rep. 11, 2692 (2021), Abstract
- PINK1-induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension: Dasgupta, A., Chen, K. H., et al.; FASEB J. 35, e21771 (2021), Abstract
- Proteasome- and Calpain-Mediated Proteolysis, but Not Autophagy, Is Required for Leucine-Induced Protein Synthesis in C2C12 Myotubes: Osburn, S. C., Vann, C. G., et al.; Physiologia 1, 22 (2021), Abstract
- Protein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress: Kim, M. J., Samluk, L., et al.; bioRxiv , (2021), Reactant(s): Human
- Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs: Chandrakumar, A. A., Coyaud, E., et al.; J. Cell Biol. 220, (2021), Abstract
- Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase: Kong, K. E., Fischer, B., et al.; Mol. Cell 81, 2460 (2021), Reactant(s): Saccharomyces cerevisiae, Abstract
- Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1: Wiegard, A., Kuzin, V., et al.; Mol. Cell 81, 5007 (2021), Abstract
- K63-linked ubiquitylation induces global sequestration of mitochondria: T.J.C. Richard, et al.; Sci. Rep. 10, 22334 (2020), Abstract — Full Text
- RING-finger protein 166 plays a novel pro-apoptotic role in neurotoxin-induced neurodegeneration via ubiquitination of XIAP: C. Oh, et al.; Cell Death Dis. 11, 939 (2020), Abstract — Full Text
- Cytokinin-induced protein synthesis suppresses growth and osmotic stress tolerance: S.S. Karunadasa, et al.; New Phytol. 227, 50 (2020), Application(s): Treatment of A. thaliana seedlings, Abstract
- Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission: Shi, L., Liu, J., et al.; Mol. Oncol. 14, 3169 (2020), Abstract
- Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation: Kelmer Sacramento, E., Kirkpatrick, J. M., et al.; Mol. Syst. Biol. 16, e9596 (2020), Abstract
- Zika virus NS2A protein induces the degradation of KPNA2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy: He, J., Yang, L., et al.; Autophagy 16, 2238 (2020), Abstract
- PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis: J. Araya, et al.; Autophagy 15, 510 (2019), Abstract
- A tumor suppressor Retinoblastoma1 is essential for embryonic development in the sea urchin: A. Fernandez-Nicolas, et al.; Dev. Dyn. 248, 1273 (2019), Abstract
- Ubiquitin-proteasome system participates in the de-aggregation of spermadhesin and DQH protein during boar sperm capacitation: M. Zigo, et al.; Reproduction 157, 283 (2019), Abstract
- Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway: Y. Wu, et al.; Am. J. Cancer Res. 9, 1682 (2019), Abstract
- PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus: A.F. Burroughs, et al.; Cell. Physiol. Biochem. 47, 800 (2019), Abstract — Full Text
- Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis: B.S. Han, et al.; Sci. Rep. 9, 2902 (2019), Application(s): protein degradation assay w/ CT26-HER2 tumor cell variants a1 and a2, Abstract — Full Text
- Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases: E. Gatti; Methods Mol. Biol. 1988, 259 (2019), Abstract
- Regulation of the translation activity of antigen-specific mRNA is responsible for antigen loss and tumor immune escape in a HER2-expressing tumor model: B.S. Han, et al.; Sci. Rep. 9, 2855 (2019), Abstract — Full Text
- Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction: K.R. Simonetta, et al.; Nat. Commun. 10, 1402 (2019), Abstract — Full Text
- Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling: G. Segala, et al.; Nat. Commun. 10, 1833 (2019), Abstract — Full Text
- The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation: W. Lu, et al.; Biochem. Biophys. Res. Commun. 514, 1185 (2019), Abstract
- SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression: Zhang, J., Chen, M., et al.; Dev. Cell 48, 329 (2019), Abstract
- Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress: Babazadeh, R., Ahmadpour, D., et al.; Cell Rep. 28, 2096 (2019), Abstract
- Interactive effects of osmotic stress and burrowing activity on protein metabolism and muscle capacity in the soft shell clam Mya arenaria: F. Haider, et al.; Comp. Biochem. Physiol. A Mol. Integr. Physiol. 228, 81 (2018), Abstract
- Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions: C.T.H. Jonker, et al.; Nat. Commun. 9, 792 (2018), Abstract — Full Text
- Modifications of the 26S proteasome during boar sperm capacitation: M. Zigo, et al.; Cell Tissue Res. 372, 591 (2018), Abstract
- PERK-mediated translational control is required for collagen secretion in chondrocytes: S. Hisanaga, et al.; Sci. Rep. 8, 773 (2018), Abstract — Full Text
- Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1: Y.H. Lee, et al.; Cancer Lett. 2018, 219 (2018), Abstract — Full Text
- A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes: Bersuker, K., Peterson, C. W. H., et al.; Dev. Cell 44, 97 (2018), Abstract
- Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance: Zhang, J., Bu, X., et al.; Nature 553, 91 (2018), Abstract
- PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products: Murata, K., Lu, W., et al.; iScience 8, 200 (2018), Abstract
- Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6: Y. Tan, et al.; Oncotarget 8, 47890 (2017), Abstract — Full Text
- The stability of Fbw7a in M-phase requires its phosphorylation by PKC: S. Zitouni, et al.; PLoS One 12, e0183500 (2017), Abstract — Full Text
- A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis: S.L. Dong, et al.; Emerg. Microbes Infect. 6, e105 (2017), Abstract — Full Text
- Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α: M. Iizuka, et al.; Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 93, 498 (2017), Abstract — Full Text
- WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels: A. Salvi, et al.; Biochem. Biophys. Res. Commun. 482, 1353 (2017), Abstract
- Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation: Prusty, A. B., Meduri, R., et al.; J. Cell Biol. 216, 2391 (2017), Abstract
- Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation: Wu, F., Dai, X., et al.; Cancer Lett. 385, 207 (2017), Reactant(s): Human, Abstract
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL: R. Yosef, et al.; Nat. Commun. 7, 11190 (2016), Abstract — Full Text
- Cytotoxicity and Proteasome Inhibition by Alkaloid Extract from Murraya koenigii Leaves in Breast Cancer Cells-Molecular Docking Studies: A. Ismail, et al.; J. Med. Food. 12, 1155 (2016), Abstract
- Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro: N. Groll, et al.; Toxicology 370, 94 (2016), Application(s): Cell culture, mouse hepatoma cells , Abstract
- Glycan-binding F-box protein from Arabidopsis thaliana protects plants from Pseudomonas syringae infection: K. Stefanowicz, et al.; BMC Plant Biol. 16, 213 (2016), Application(s): Hormone treatments, abiotic stress applications and infection assays on WT A. thaliana plants, Abstract — Full Text
- Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors: L. Zhang, et al.; Mol. Oncol. 10, 1099 (2016), Application(s): In vitro exposure of the cells to drugs, Abstract
- LRRK2 interferes with aggresome formation for autophagic clearance: Y. Bang, et al.; Moll. Cell Neurosci. 75, 71 (2016), Application(s): Induced protein quality control-associated autophagy in mice to uncover how the autophagy pathway is affected, Abstract
- Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells: M. McNaughton, et al.; Oncotarget 7, 16663 (2016), Application(s): Cell culture, Abstract — Full Text
- Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells: C.A. Tang, et al.; Cancer Res. 76, 2137 (2016), Application(s): Stimulated cells, Abstract — Full Text
- Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells: T. Fujie, et al.; J. Biol. Inorg. Chem. 21, 263 (2016), Application(s): Cell culture, Abstract — Full Text
- HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity: Y. Otaki, et al.; J. Am. Heart Assoc. 5, e002485 (2016), Application(s): Incubated into rat cardiomyocytes, Abstract — Full Text
- Adjustments of Protein Metabolism in Fasting Arctic Charr, Salvelinus alpinus: A.A. Cassidy, et al.; PLoS One 11, e0153364 (2016), Application(s): 20S proteasome activity, Abstract — Full Text
- Posttranscriptional control of NLRP3 inflammasome activation in colonic macrophages: A.A. Filardy, et al.; Mucosal Immunol. 9, 850 (2016), Application(s): Cell culture, Abstract
- Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death: C. Kim, et al.; Cell Death Differ. 23, 333 (2016), Application(s): Cell Culture, Abstract
- PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability: K. Nakagawa, et al.; Biochem. Biophys. Res. Commun. 469, 470 (2016), Application(s): Immunoprecipitation and Western blotting, Abstract
- D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly: P. Barroso-Chinea, et al.; Neurobiol. Dis. 78, 77 (2015), Application(s): Assay, Abstract
- Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog. 11, e1004725 (2015), Application(s): Cell Culture, Abstract — Full Text
- A point mutation in the ubiquitin ligase RNF170 that causes autosomal dominant sensory ataxia destabilizes the protein and impairs inositol 1,4,5-trisphosphate receptor-mediated Ca2+ signaling: F.A. Wright, et al.; J. Biol. Chem. 290, 13948 (2015), Application(s): Cell Culture, Abstract — Full Text
- Fatty acids increase adiponectin secretion through both classical and exosome pathways: V. DeClercq, et al.; Biochim. Biophys. Acta 1851, 1123 (2015), Application(s): Cell Culture, Abstract
- Molecular Consequences of Defective SERPINH1/HSP47 in the Dachshund Natural Model of Osteogenesis Imperfecta: U. Lindert, et al.; J. Biol. Chem. 290, 17679 (2015), Application(s): Cell Culture, Western Blot, Abstract — Full Text
- RGS19 Converts Iron Deprivation Stress into a Growth-Inhibitory Signal: J. Hwang, et al.; Biochem. Biophys. Res. Commun. 464, 168 (2015), Application(s): Cell Culture, Abstract
- Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells: K. Husmann, et al.; Biochem. Biophys. Res. Commun. 464, 1222 (2015), Application(s): Cell Culture, Abstract
- ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function: D. Cui, et al.; Sci. Rep. 5, 12796 (2015), Application(s): Cell Culture, Abstract
- Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1α expression during tumor progression: W.Y. Bae, et al.; Biochem. Pharmacol. 98, 41 (2015), Application(s): Cell culture , Abstract
- NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes Proteasomal Degradation of Misfolded Proteins: J. Li, et al.; J. Biol. Chem. 290, 23850 (2015), Application(s): Proteasomal peptidase activity assay, Abstract — Full Text
- UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP: Y. Teng, et al.; Biochem. Pharmacol. 97, 518 (2015), Application(s): Cell culture, Abstract
- The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells: Rui, Y. N., Xu, Z., et al.; Autophagy 11, 812 (2015), Reactant(s): Human, Abstract
- The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract — Full Text
- Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells: A. Sato, et al.; Stem Cell Res. 12, 119 (2014), Application(s): WB of human glioma-initiating cells, Abstract
- Kizuna is a novel mitotic substrate for CDC25B phosphatase: Y. Thomas, et al.; Cell Cycle 13, 3867 (2014), Application(s): HeLa, U2OS, and U2OS Tet-off cells analyzed by IP, IF , Abstract — Full Text
- Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa: S. Zimmerman, et al.; Cell Tissue Res. 356, 261 (2014), Application(s): IF, WB of boar, mouse and human sperm , Abstract
- Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR: S. Ivanov & C. Roy; Nat. Immunol. 14, 1219 (2013), Application(s): Analysis of mouse macrophages by WB, PCR, Abstract — Full Text
- A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis: L. Shao, et al.; PLoS One 8, e62223 (2013), Application(s): IF, WB of mouse intestinal epithelial cells , Abstract — Full Text
- The ubiquitin proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic beta cells: A. Hofmeister-Brix, et al.; Biochem. J. 456, 173 (2013), Abstract — Full Text
- Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death: A. Bartolome, et al.; Autophagy 8, 1757 (2012), Application(s): Flow cytometry of fetal pancreatic β cells , Abstract — Full Text
- SUMO E3 ligase activity of TRIM proteins: Y. Chu & X. Yang; Oncogene 30, 1108 (2011), Application(s): Mammalian in vitro cells analyzed by WB, Abstract — Full Text
- Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies: D. Shen, et al.; Cell Biochem. Biophys. 60, 173 (2011), Abstract — Full Text
- Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species: K.D. Salway, et al.; Age 33, 33 (2011), Abstract
- Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells: W.K. Wu, et al.; BBRC 374, 258 (2008), Abstract
- Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression: L. Salmena, et al.; Biochem. Pharmacol. 61, 795 (2001), Abstract
- Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis: A.B. Meriin, et al.; J. Biol. Chem. 273, 6373 (1998), Abstract
- Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance: K.T. Bush, et al.; J. Biol. Chem. 272, 9086 (1997), Abstract
- Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine: S. Tsubuki, et al.; J. Biochem. 119, 572 (1996), Abstract
- Chapter 28. Novel Inhibitors of the Proteasome and Their Therapeutic Use in Inflammation: J. Adams & R. Stein; Ann. Rep. Med. Chem. 31, 279 (1996)
- The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol: E.J. Wiertz, et al.; Cell 84, 769 (1996), Abstract
- Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae: D.H. Lee & A.L. Goldberg; J. Biol. Chem. 271, 27280 (1996), Abstract
- The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression: M.A. Read, et al.; Immunity 2, 493 (1995), Abstract
- Multiple proteolytic systems, including the proteasome, contribute to CFTR processing: T.J. Jensen, et al.; Cell 83, 129 (1995), Abstract
- Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules: K.L. Rock, et al.; Cell 78, 761 (1994), Abstract
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