MG-115

ALX-260-091

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Proteasome inhibitor

Potent, reversible proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.

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Product Details

Alternative Name	Z-LL-Nva-CHO, Z-Leu-Leu-Nva-CHO
Appearance	White to off-white powder.
CAS	133407-86-0
Formula	C₂₅H₃₉N₃O₅
MW	461.6
Purity	≥95% (HPLC)
Sequence	Z-Leu-Leu-Nva-CHO
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay: Zmuda, F., Sastry, L., et al.; Antimicrob. Agents Chemother. 63, (2019), Reactant(s): Trypanosoma cruzi, Abstract
p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9: J. Won Yoon, et al.; DNA Repair (Amst.) 34, 9 (2015), Application(s): Western Blot, Abstract
Ras is involved in the negative control of autophagy through the class I PI3-kinase: S. Furuta, et al.; Oncogene 23, 3898 (2004), Abstract
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression: L. Salmena, et al.; Biochem. Pharmacol. 61, 795 (2001), Abstract
Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death: J.N. Keller & W.R. Markesbery; J. Neurosci. Res. 61, 436 (2000), Abstract
p53-dependent induction of apoptosis by proteasome inhibitors: U.G. Lopes, et al.; J. Biol. Chem. 272, 12893 (1997), Abstract — Full Text
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae: D.H. Lee & A.L. Goldberg; J. Biol. Chem. 271, 27280 (1996), Abstract — Full Text
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B: V.J. Palombella, et al.; Cell 78, 773 (1994), Abstract
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules: K.L. Rock, et al.; Cell 78, 761 (1994), Abstract
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex: A. Vinitsky, et al.; Biochemistry 31, 9421 (1992), Abstract

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MG-115

ALX-260-091

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