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Mevastatin

BML-G233

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HMG-CoA reductase inhibitor

Mevastatin inhibits isoprenoid biosynthesis by inhibition of HMG-CoA reductase (K_i for acid form is 1 nM) and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. It causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

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Product Details

Alternative Name	Compactin
Appearance	White to off-white solid.
CAS	73573-88-3
Couple Target	HMG-CoA reductase
Couple Type	Inhibitor
Formula	C₂₃H₃₄O₅
Identity	Determined by 1H-NMR.
MW	390.5
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (20mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P): da Palma, J. R., Cendron, L., et al.; J. Biol. Chem. 291, 2055 (2016), Abstract
Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease: da Palma, J. R., Burri, D. J., et al.; J. Biol. Chem. 289, 35743 (2014), Abstract
Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P): Burri, D. J., da Palma, J. R., et al.; J. Virol. 87, 6406 (2013), Abstract
Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease: Burri, D. J., Pasqual, G., et al.; J. Virol. 86, 4935 (2012), Abstract
Activation of autophagy of aggregation-prone ubiquitinated proteins by timosaponin A-III: Lok, C. N., Sy, L. K., et al.; J. Biol. Chem. 286, 31684 (2011), Abstract
The discovery and development of HMG-CoA reductase inhibitors: A. Endo; J. Lipid Res. 33, 1569 (1992), Abstract
The dual role of mevalonate in the cell cycle: V. Quesney-Huneeus, et al.; J. Biol. Chem. 258, 378 (1983), Abstract
Essential role for mevalonate synthesis in DNA replication: V. Quesney-Huneeus, et al.; PNAS 76, 5056 (1979), Abstract

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Mevastatin

BML-G233

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