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Methyl Arachidonyl Fluorophosphonate

BML-ST360

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Phospholipase inhibitor

Selective, active-site directed, irreversible inhibitor of cPLA₂ (IC₅₀=5µM) and Ca²⁺-independent iPLA₂(IC₅₀=0.5µM).Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀=2.5nM), 800 -fold more potent than AACOCF₃ (Prod. No. BML-ST335)). Irriversible CB₁ receptor antagonist in rat brain membrane (IC₅₀=20nM).

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Product Details

Alternative Name	MAFP, Methylphosphonofluoridic acid 5,8,11,14-eicosatetraenyl ester
Appearance	Colorless to yellow oil.
CAS	188404-10-6
Couple Target	Cannabinoid receptor, FAAH, Phospholipase, PLA
Couple Type	Inhibitor
Formula	C₂₁H₃₆FO₂P
MW	370.5
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol (50mg/ml) or DMSO (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -80°C. Stock solutions are stable for up to 2 months at -20°C.
Handling	Protect from air.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase: D.G. Deutsch, et al.; Biochem. Pharmacol. 53, 255 (1997), Abstract
Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist: S.R. Fernando & R.G.Pertwee; Br. J. Pharmacol. 121, 1716 (1997), Abstract
Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages: J. Balsinde & E.A. Dennis; J. Biol. Chem. 271, 6758 (1996), Abstract — Full Text
Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate: Y.C. Lio, et al.; Biochim. Biophys. Acta 1302, 55 (1996), Abstract

Related Products

AACOCF3

BML-ST335

Inhibitor of PLA₂ and FAAH

11 citations

CAS	149301-79-1
Couple Type	Inhibitor
Purity	≥98% (TLC)

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Methyl Arachidonyl Fluorophosphonate

BML-ST360

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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