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Methoxsalen

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Cytochrome P450 inhibitor

A potent suicide inhibitor of cytochrome P450. Antipsoriatic activity following ultraviolet light exposure.

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Alternative Name	Xanthotoxin
Appearance	White to yellow powder.
CAS	298-81-7
Couple Target	Cytochrome P450
Couple Type	Inhibitor
Formula	C₁₂H₈O₄
MW	216.2
Purity	≥98% (GC)
Solubility	Soluble in acetone or hot ethanol (slight).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice: G. Labbe, et al.; Biochem. Pharmacol. 36, 907 (1987), Abstract
Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats: P. Letteron, et al.; J. Pharmacol. Exp. Ther. 238, 685 (1986), Abstract
Oral methoxsalen photochemotherapy for the treatment of psoriasis: a cooperative clinical trial: J.W. Melski, et al.; J. Invest. Dermatol. 68, 328 (1977), Abstract

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