Home Shop Metallothionein monoclonal antibody (UC1MT)

Metallothionein monoclonal antibody (UC1MT)

ADI-SPA-550

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Metallothioneins (MTs) are a class of ubiquitous, low molecular weight, cysteine-rich, metal binding proteins that function in the metabolism of zinc and copper. MT protects against exposure to toxic metals such as mercury and cadmium as well as a variety of other stress conditions. There are four mammalian MT isoforms: MT-I, -II, -III, -IV, each of which is encoded by individual genes. MT expression is induced by heavy metal cations, starvation, elevated temperature, lipopolysaccharide, inflammatory cytokines, free radicals, and ionizing radiation.

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This antibody is covered by our Worry-Free Guarantee.

Metallothionein monoclonal antibody (UC1MT) Immunohistochemistry — Immunohistochemistry analysis of human uterus tissue stained with Metallothionein, mAb (UC1MT) at 10µg/ml.

Metallothionein monoclonal antibody (UC1MT) Western blot — Western blot analysis of Prod. No. ADI-SPA-550: Lane 1: MW marker, Lane 2: MT I, Lane 3: MT II, Lane 4: Mummichug CdCl2.

Product Details

Alternative Name	MT1A, Metallothionein MGC32848, MT1S, MTC, metallothionein 1A (functional)
Application	ELISA, IHC (PS), WB
Application Notes	Detects a band of ~15kDa by Western blot.
Clone	UC1MT
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Host	Mouse
Immunogen	Cross-linked rabbit liver Metallothionein I and II.
Isotype	IgG1
Purity Detail	Protein G affinity purified.
Recommendation Dilutions/Conditions	Western Blot (1:1,000, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from ascites.
Species Reactivity	Fish, Horse, Human, Mouse, Rabbit, Rat
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The protease DDI2 regulates NRF1 activation in response to cadmium toxicity: S.T. Ribeiro, et al.; iScience 25, 105227 (2022), Application(s): WB, Abstract
Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1: Mathieu, C., Chamayou, Q., et al.; Eur. J. Med. Chem. 229, 114052 (2022), Abstract
Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice.: Forte, E., Skelly, D. A., et al.; Cell Rep. 30, 3149 (2020), Application(s): IF, Abstract
Reduced hepatic metallothionein expression in first trimester fetuses in response to intrauterine smoking exposure: a consequence of low maternal zinc levels?: Bilde, K., Olesen, R. H., et al.; Hum. Reprod. 34, 2129 (2019), Abstract
Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride.: R. Macirella & E. Brunelli; Int. J. Mol. Sci. 18, 824 (2017), Abstract — Full Text
Effects of Two Sublethal Concentrations of Mercury Chloride on the Morphology and Metallothionein Activity in the Liver of Zebrafish (Danio rerio): R. Macirella, et al.; Int. J. Mol. Sci. 17, e361 (2016), Application(s): Immunohistochemistry, Abstract — Full Text
Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity: Zhao, Y., Feresin, R. G., et al.; Traffic 17, 267 (2016), Abstract
Metallothioneins and heat shock proteins 70 in Armadillidium vulgare (Isopoda, Oniscidea) exposed to cadmium and lead: V. Mazzei, et al.; Ecotoxicol. Environ. Saf. 116, 99 (2015), Application(s): Immunohistochemistry, Western Blotting , Abstract
Potentiation of cadmium-induced cytotoxicity by sulfur amino acid deprivation through activation of extracellular signal-regulated kinase1/2 (ERK1/2) in conjunction with p38 kinase or c-jun N-terminal kinase (JNK). Complete inhibition of the potentiated t: S.G. Kim, et al.; Biochem. Pharmacol. 62, 1379 (2001), Application(s): WB using rat samples, Abstract
Identification and spatial analysis of metallothioneins expressed by the adult human lens: M. Kantorow, et al.; Invest. Ophthalmol. Vis. Sci. 42, 188 (2001), Application(s): WB using human samples, Abstract

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Last modified: May 29, 2024

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Metallothionein monoclonal antibody (UC1MT)

ADI-SPA-550

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Metallothionein monoclonal antibody (UC1MT)

ADI-SPA-550

Product Details

Handling & Storage

Related Products

HeLa (heat shocked) , (cell lysate)

ADI-LYC-HL101

Goat anti-mouse IgG F(ab’)2, polyclonal antibody (HRP conjugate)

ADI-SAB-100

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Goat anti-mouse IgG F(ab’)₂, polyclonal antibody (HRP conjugate)