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Memantine . hydrochloride

ALX-550-363

9 citations

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NMDA receptor antagonist

Low-affinity NMDA receptor antagonist. Stimulates dopamine release.

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Product Details

Alternative Name	1-Amino-3,5-dimethyladamantane . HCl, 3,5-Dimethyl-1-aminoadamantane . HCl
Appearance	White powder.
CAS	41100-52-1
Couple Target	NMDA receptor
Couple Type	Inhibitor, Ligand
Formula	C₁₂H₂₁N . HCl
MI	14: 5829
MW	179.3 . 36.5
Purity	≥98% (Argentmetric Titration)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats: Mihara, Y., Egashira, N., et al.; Mol. Pain 7, 8 (2011), Abstract
Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist–a review of preclinical data: C.G. Parsons, et al.; Neuropharmacology 38, 735 (1999), (Review), Abstract
Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze lea: H.S. Chen, et al.; Neuroscience 86, 1121 (1998), Abstract
Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by N-methyl-D-aspartate receptor antagonist, memantine: P. Popik & W. Danysz; J. Pharmacol. Exp. Ther. 280, 854 (1997), Abstract
Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism: H.S. Chen & S.A. Lipton; J. Physiol. 499, 27 (1997), Abstract
Trapping channel block of NMDA-activated responses by amantadine and memantine: T.A. Blanpied, et al.; J. Neurophysiol. 77, 309 (1997), Abstract
Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices: T. Frankiewicz, et al.; Br. J. Pharmacol. 117, 689 (1996), Abstract
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity: H.S. Chen, et al.; J. Neurosci. 12, 4427 (1992), Abstract
Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones: N.N. Osborne & G. Quack; Neurochem. Int. 21, 329 (1992), Abstract

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Memantine . hydrochloride

ALX-550-363

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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